• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans.
【24h】

Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans.

机译：从人的多普勒早期充盈减速时间估算左心室操作刚度。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Shortened early transmitral deceleration times (E(DT)) have been qualitatively associated with increased filling pressure and reduced survival in patients with cardiac disease and increased left ventricular operating stiffness (K(LV)). An equation relating K(LV) quantitatively to E(DT) has previously been described in a canine model but not in humans. During several varying hemodynamic conditions, we studied 18 patients undergoing open-heart surgery. Transesophageal echocardiographic two-dimensional volumes and Doppler flows were combined with high-fidelity left atrial (LA) and left ventricular (LV) pressures to determine K(LV). From digitized Doppler recordings, E(DT) was measured and compared against changes in LV and LA diastolic volumes and pressures. E(DT) (180 +/- 39 ms) was inversely associated with LV end-diastolic pressures (r = -0.56, P 0.004) and net atrioventricular stiffness (r its strongest association with K(LV) (r = -0.81, P < 0.001). K(LV) was predicted assuming a nonrestrictive orifice (K(nonrest)) from E(DT) as K(nonrest) = (0.07/E(DT))(2) with K(LV) = 1.01 K(nonrest) - 0.02; r = 0.86, P < 0.001, DeltaK (K(nonrest) - K(LV)) = 0.02 +/- 0.06 mm Hg/ml. In adults with cardiac disease, E(DT) provides an accurate estimate of LV operating stiffness and supports its application as a practical noninvasive index in the evaluation of diastolic function.
机译：从质量上讲，缩短的早期穿刺减速时间（E（DT））与充盈压力增加和心脏病患者生存率降低以及左心室操作僵硬度（K（LV））增加有关。先前已经在犬模型中描述了定量地将K（LV）与E（DT）相关的方程式，但在人类中却没有描述。在几种不同的血液动力学条件下，我们研究了18名接受心脏直视手术的患者。经食道超声心动图二维体积和多普勒血流与高保真左心房（LA）和左心室（LV）压力相结合以确定K（LV）。从数字化多普勒记录中，测量E（DT）并将其与LV和LA舒张容积和压力的变化进行比较。 E（DT）（180 +/- 39 ms）与左室舒张末期压力（r = -0.56，P 0.004）和房室净硬度（r与K（LV）的最强关联（r = -0.81， P <0.001）。假设来自E（DT）的非限制性节流孔（K（nonrest））为K（nonrest）=（0.07 / E（DT））（2），且K（LV）= 1.01，则预测K（LV） K（非静止）-0.02; r = 0.86，P <0.001，DeltaK（K（非静止）-K（LV））= 0.02 +/- 0.06 mm Hg / ml。在患有心脏病的成人中，E（DT）提供LV操作刚度的准确估计，并支持其作为舒张功能评估中的实用无创性指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号