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首页> 外文期刊>American Journal of Physiology >Postnatal changes in inhibitory effect of C-type natriuretic peptide on secretion of ANP.
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Postnatal changes in inhibitory effect of C-type natriuretic peptide on secretion of ANP.

机译：产后C型利钠肽对ANP分泌抑制作用的变化。

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摘要

To define developmental changes in atrial natriuretic peptide (ANP) secretion and in the cross talk between C-type natriuretic peptide (CNP) and ANP, we performed experiments in isolated perfused nonbeating cardiac atria isolated from rabbits between 1 and 8 wk of age. Changes in atrial pressure resulted in increases in atrial volume that rose with age and reached the peak value at 4 wk. A rise in volume change increased ANP secretion with concomitant translocation of extracellular fluid (ECF) into the atrial lumen, which increased with age and reached the peak value at 4 wk. The positive relationship between stretch-induced ANP secretion and ECF translocation shifted upward and leftward with age. CNP suppressed stretch-induced ANP secretion in the 8-wk-old group but not in the 2- and 4-wk-old groups without differences in ECF translocation and atrial volume. Therefore, the ANP secretion in terms of ECF translocation was markedly suppressed by CNP in the 8-wk-old group but not in the 2- and 4-wk-old groups. The production of cGMP by CNP in atrial tissue membranes was markedly attenuated in young rabbits. However, 8-bromo-cGMP suppressed stretch-induced ANP secretion in 2- and 8-wk-old groups. Natriuretic peptide receptor-B mRNA was similar in both groups. Therefore, we conclude that the inhibitory effect of CNP on atrial ANP secretion is developmentally regulated, being absent during normal cardiac development in young animals and intact in adult animals.
机译：为了确定心房利钠肽（ANP）分泌以及C型利尿钠肽（CNP）与ANP之间的相互干扰的发育变化，我们在从1至8周龄的兔子中分离出的无搏动性心房进行了实验。心房压力的变化导致心房容量的增加，其随着年龄的增长而上升，并在4周时达到峰值。体积变化的增加增加了ANP的分泌，伴随着细胞外液（ECF）向心腔的转移，随着年龄的增长而增加，并在4周时达到峰值。牵拉诱导的ANP分泌与ECF移位之间的正相关关系随着年龄的增长而向上和向左移动。 CNP在8周龄组中抑制了拉伸诱导的ANP分泌，但在2周龄和4周龄组中没有抑制，而ECF移位和心房容量无差异。因此，在8周龄组中，CNP显着抑制了根据ECF易位的ANP分泌，而在2周龄组和4周龄组中则没有。在幼兔中，CNP在心房组织膜中产生的cGMP明显减弱。但是，在2和8周龄组中，8-溴-cGMP抑制了拉伸诱导的ANP分泌。两组的利钠肽受体-B mRNA相似。因此，我们得出结论，CNP对心房ANP分泌的抑制作用是发育性调节的，在幼年动物的正常心脏发育过程中是不存在的，而在成年动物中则是完整的。

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