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首页> 外文期刊>American Journal of Physiology >Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.
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Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.

机译：Ghrelin /胃动素相关肽是一种有效的促动剂，可逆转大鼠胃术后肠梗阻。

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摘要

A novel peptide called ghrelin or motilin-related-peptide (MTLRP) was found in the stomach of various mammals. We studied its effect on the motor function of the rat gastrointestinal tract. In normal, conscious unoperated animals, ghrelin/MTLRP (5 or 20 microg/kg iv) significantly accelerated the gastric emptying of a methylcellulose liquid solution (gastric residue after 15 min: 57 +/- 7, 42 +/- 11, 17 +/- 4, and 9 +/- 3% of the ingested meal with doses of 0, 1, 5, and 20 microg/kg iv, respectively) Transit of the methylcellulose liquid solution was also accelerated by ghrelin/MTLRP in the small intestine but not in the colon. Des-[Gln(14)]ghrelin, also found in the mammalian stomach, was as potent as ghrelin in emptying the stomach (gastric residue after 15 min: 12 +/- 3% at a dose of 20 microg/kg iv). In rats in which postoperative gastrointestinal ileus had been experimentally induced, ghrelin/MTLRP (20 microg/kg iv) reversed the delayed gastric evacuation (gastric residue after 15 min: 28 +/- 7% of the ingested meal vs. 82 +/- 9% with saline). In comparison, the gastric ileus was not modified by high doses of motilin (77 +/- 7%) or erythromycin (82 +/- 6%) and was only partially improved by calcitonin gene-related peptide (CGRP) 8-37 antagonist (59 +/- 7%). Ghrelin/MTLRP, therefore, accelerates the gastric emptying and small intestinal transit of a liquid meal and is a strong prokinetic agent capable of reversing the postoperative gastric ileus in rat.
机译：在各种哺乳动物的胃中发现了一种称为生长素释放肽或胃动蛋白相关肽（MTLRP）的新型肽。我们研究了其对大鼠胃肠道运动功能的影响。在正常，无意识的未手术动物中，生长素释放肽/ MTLRP（5或20微克/千克，静脉注射）可显着加速胃部甲基纤维素液体溶液的排空（15分钟后的胃残余物：57 +/- 7、42 +/- 11、17 +分别为0、1、5和20 microg / kg iv的摄入膳食的4％和9 +/- 3％）ghrelin / MTLRP还促进了小肠中甲基纤维素液体溶液的转运但不在结肠。在哺乳动物的胃中也发现的Des- [Gln（14）] ghrelin与胃饥饿素在排空胃中的作用一样强（15分钟后的胃残余物：剂量为20 microg / kg iv时为12 +/- 3％）。在实验上诱发了术后肠梗阻的大鼠中，ghrelin / MTLRP（20 microg / kg iv）逆转了延迟的胃排空（15分钟后的胃残余物：进食量的28 +/- 7％与82 +/- 9％的盐水）。相比之下，高剂量的胃动素（77 +/- 7％）或红霉素（82 +/- 6％）不会改变胃肠梗阻，而降钙素基因相关肽（CGRP）8-37拮抗剂只能部分改善胃回肠（59 +/- 7％）。因此，Ghrelin / MTLRP加速了胃液的胃排空和小肠运输，并且是一种能够逆转大鼠术后肠梗阻的强促运动剂。

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