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首页> 外文期刊>American Journal of Physiology >Increased coronary blood flow signals growth of coronary resistance vessels in near-term ovine fetuses.
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Increased coronary blood flow signals growth of coronary resistance vessels in near-term ovine fetuses.

机译：冠状动脉血流量的增加表明近期绵羊胎儿中冠状动脉阻力血管的生长。

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We measured maximal coronary artery conductance in near-term fetal sheep before and after chronic infusion with adenosine to determine whether an increase in coronary flow without hypoxemia results in increased coronary vascular growth. Adenosine was infused into the circumflex coronary artery for 12 h each day for 4 days. Coronary flow was maintained at double the resting level by regulating the infusion of adenosine via a computerized servocontrol device signaled by a Doppler flow-velocity sensor. Total arterial hemoglobin, oxygen content, and hemodynamics were unchanged. Resting circumflex coronary blood flow increased from control of 250 +/- 111 to 530 +/- 216 ml x min(-1) x 100 g left ventricle(-1) with adenosine on day 1 and from 194 +/- 74 to 878 +/- 210 ml x min(-1) x 100 g left ventricle(-1) with adenosine on the last day (P < 0.01). Coronary conductance, determined during maximal vasodilation, increased from 14.0 +/- 5.0 to 26.9 +/- 3.9 ml x min(-1) x 100 g(-1) x mmHg(-1) over the 4 days (P <0.001). Coronary flow reserve, the difference between resting and maximal myocardial blood flow interpolated at 40 mmHg, increased from 299 +/- 196 to 672 +/- 266 ml x min(-1) x 100 g(-1) (P < 0.001). Maximal coronary conductance was unchanged in control saline-infused fetuses (18.5 +/- 5.1 vs. 18.5 +/- 8.7 ml x min(-1) x 100 g(-1) x mmHg(-1)). We conclude that chronic intracoronary adenosine administration to the fetal myocardium modulates coronary vascular growth, even in the absence of tissue hypoxia.
机译：我们在长期输注腺苷之前和之后测量了近期胎羊的最大冠状动脉电导率，以确定在没有低氧血症的情况下冠状动脉血流的增加是否会导致冠状血管的生长增加。每天将腺苷注入回旋支冠状动脉中，持续12天，持续4天。通过由多普勒流速传感器发出信号的计算机伺服控制装置调节腺苷的输注，可将冠状动脉血流保持在静息状态的两倍。总动脉血红蛋白，氧含量和血流动力学均未改变。第1天静息回旋冠状动脉血流量从控制的250 +/- 111增加到530 +/- 216 ml x min（-1）x 100 g左心室（-1）和腺苷，从194 +/- 74增加到878在最后一天用腺苷+/- +/- 210 ml x min（-1）x 100 g左心室（-1）（P <0.01）。在最大血管舒张期确定的冠状动脉电导率在4天中从14.0 +/- 5.0增至26.9 +/- 3.9 ml x min（-1）x 100 g（-1）x mmHg（-1）（P <0.001） 。冠状动脉血流储备，在40 mmHg时内插的静息和最大心肌血流之间的差异从299 +/- 196升至672 +/- 266 ml x min（-1）x 100 g（-1）（P <0.001） 。对照盐水注入胎儿的最大冠状动脉电导率不变（18.5 +/- 5.1 vs. 18.5 +/- 8.7 ml x min（-1）x 100 g（-1）x mmHg（-1））。我们得出的结论是，即使不存在组织缺氧，对胎儿心肌进行慢性冠状动脉内腺苷给药也会调节冠状血管的生长。

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