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首页> 外文期刊>American Journal of Physiology >Effect of feeding diets of varying fatty acid composition on apolipoprotein expression in newborn swine.
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Effect of feeding diets of varying fatty acid composition on apolipoprotein expression in newborn swine.

机译：饲喂不同脂肪酸组成的日粮对新生猪载脂蛋白表达的影响。

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摘要

The purpose of this study was to determine the effect of chronic (1 wk) feeding of dietary triacylglycerol (TG) of varying fatty acid composition on small intestinal and hepatic apolipoprotein expression, as well as serum lipid and apolipoprotein concentrations, in newborn swine. Two-day-old female swine were fed one of three diets by gavage with the following lipid composition: medium-chain TG (MCT; MCT oil), intermediate-chain saturated TG (ICST; coconut oil), and long-chain polyunsaturated TG (LCPUT; safflower oil) at 753 kJ . kg-1 . day-1 with 51% of energy from fat. After 1 wk, serum lipids and apolipoprotein concentrations were measured, and jejunal apolipoprotein B (apo B) and apo A-I mass and apo B, apo A-I, apo A-IV, and apo C-III synthesis were measured. Liver was processed for determination of apo B and apo A-I mass and apo B, apo A-I, apo C-III, and beta-actin mRNA abundance by slot blot hybridization. Compared with the MCT and LCPUT groups, the ICST group had higher total serum cholesterol, TG, high-density lipoprotein (HDL)-cholesterol, and apo A-I concentrations. There were no differences among the three groups for intestinal apolipoprotein mass or synthesis. In liver, apo A-I mass was highest in the ICST group. Liver apo A-I and apo C-III mRNA abundance was highest in the ICST group. Among all three groups, hepatic apo A-I mass correlated significantly with plasma HDL-cholesterol concentrations, and serum TG concentrations correlated with hepatic apo C-III mRNA abundance. In conclusion, we found that in the newborn piglet, chronic feeding of ICST increases serum total cholesterol, TG, HDL-cholesterol, and apo A-I concentrations and hepatic expression of apo A-I and apo C-III mRNA, compared with feeding of MCT or LCPUT. We speculate that increased hepatic apo A-I expression may contribute to the higher serum HDL and apo A-I concentrations in the ICST animals. Increased hepatic expression of apo C-III with ICST feeding may contribute to the higher serum TG concentrations by apo C-III-mediated inhibition of the catabolism of triacylglycerol-rich lipoproteins.
机译：这项研究的目的是确定长期（1周）饲喂不同脂肪酸组成的饮食三酰甘油（TG）对新生猪小肠和肝载脂蛋白表达以及血清脂质和载脂蛋白浓度的影响。对两天大的母猪进行以下三种脂质组成的饲喂：三种饮食之一：中链TG（MCT; MCT油），中链饱和TG（ICST;椰子油）和长链多不饱和TG （LCPUT;红花油）于753 kJ。千克-1。第一天的脂肪中有51％的能量来自于脂肪。 1周后，测量血脂和载脂蛋白浓度，并测量空肠载脂蛋白B（载脂蛋白B）和载脂蛋白A-I质量以及载脂蛋白B，载脂蛋白A-I，载脂蛋白A-IV和载脂蛋白C-III的合成。通过缝隙印迹杂交处理肝脏以测定载脂蛋白B和载脂蛋白A-I的质量以及载脂蛋白B，载脂蛋白A-I，载脂蛋白C-III和β-肌动蛋白mRNA的丰度。与MCT和LCPUT组相比，ICST组的总血清胆固醇，TG，高密度脂蛋白（HDL）-胆固醇和载脂蛋白A-I浓度更高。三组之间的肠载脂蛋白质量或合成没有差异。在肝脏中，ICST组的载脂蛋白A-I质量最高。在ICST组中，肝脏载脂蛋白A-I和载脂蛋白C-III mRNA的丰度最高。在这三组中，肝载脂蛋白A-I含量与血浆HDL-胆固醇浓度显着相关，血清TG浓度与肝载脂蛋白C-III mRNA丰度相关。总之，我们发现，与MCT或LCPUT饲喂相比，ICSST的长期饲喂增加了血清总胆固醇，TG，HDL-胆固醇和apo AI的浓度以及apo AI和apo C-III mRNA的肝表达。 。我们推测，肝脏apo A-I表达的增加可能有助于在ICST动物中更高的血清HDL和apo A-I浓度。通过ICST喂养，载脂蛋白C-III的肝表达增加，可能是由载脂蛋白C-III介导的富含三酰基甘油的脂蛋白分解代谢的抑制作用导致较高的血清TG浓度。

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