• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Osmotically inactive skin Na+ storage in rats.
【24h】

Osmotically inactive skin Na+ storage in rats.

机译：在大鼠中渗透性失活的皮肤Na +储存。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Compared with age-matched men, women are resistant to the hypertensive effects of dietary NaCl; however, after menopause, the incidence of salt-sensitive hypertension is similar in women and men. We recently suggested that osmotically inactive Na+ storage contributes to the development of salt-sensitive hypertension. The connective tissues, including those immediately below the skin that may serve as a reservoir for osmotically inactive Na+ storage, are affected by menopause. We tested the hypothesis that ovariectomy (OVX) might reduce osmotically inactive Na+ storage capacity in the body, particularly in the skin. Male, female-fertile, and female OVX Sprague-Dawley (SD) rats were fed a high (8%)- or low (0.1%)-NaCl diet. The groups received the diet for 4 or 8 wk. At the end of the experiment, subgroups received 0.9% saline infusion and urinary Na+ and K+ excretion was measured. Wet and dry weight (DW), water content in the body and skin, total body Na+ (rTBNa+) and skin Na+ (rSKNa+) content were measured relative to DW by desiccation and dry ashing. There were no gender differences in osmotically inactive Na+ storage in SD rats. All SD rats accumulated Na+ if fed 8% NaCl, but rTBNa+ was lower in OVX rats than in fertile rats on a low (P < 0.001)- and a high (P < 0.05)-salt diet. OVX decreased rSKNa+ (P < 0.01) in the rats. A high-salt diet led to Na+ accumulation (DeltaSKNa+) in the skin in all SD rats. Osmotically inactive skin Na+ accumulation was approximately 66% of DeltaSKNa+ in female and 82% in male-fertile rats, but there was no osmotically inactive Na+ accumulation in OVX rats fed 8% NaCl. We conclude that skin is an osmotically inactive Na+ reservoir that accumulates Na+ when dietary NaCl is excessive. OVX leads to an acquired reduction of osmotically inactive Na+ storage in SD rats that predisposes the rats to volume excess despite a reduced Na+ content relative to body weight.
机译：与年龄相匹配的男性相比，女性对饮食中氯化钠的高血压有抵抗力。然而，更年期后，男女对盐敏感性高血压的发生率相似。我们最近建议，渗透性非活性Na +储存有助于盐敏感性高血压的发展。结缔组织，包括紧接皮肤下的那些可能充当渗透性非活性Na +储存库的组织，都受到更年期的影响。我们检验了以下假设：卵巢切除术（OVX）可能会减少体内渗透性失活的Na +储存能力，尤其是皮肤。给雄性，雌性可育和雌性OVX Sprague-Dawley（SD）大鼠喂食高（8％）-或低（0.1％）-NaCl饮食。各组接受4或8周的饮食。在实验结束时，亚组接受0.9％的生理盐水输注，并测量尿液中Na +和K +的排泄量。通过干燥和灰化相对于DW测量干湿重（DW），身体和皮肤中的水分，总Na +（rTBNa +）和皮肤Na +（rSKNa +）含量。在SD大鼠中，在无渗透活性的Na +储存中没有性别差异。如果进食低盐（P <0.001）和高盐（P <0.05）的饮食，所有SD大鼠在进食8％NaCl时会积累Na +，但OVX大鼠的rTBNa +低于可育大鼠。 OVX降低了大鼠的rSKNa +（P <0.01）。高盐饮食会导致所有SD大鼠皮肤中的Na +积累（DeltaSKNa +）。渗透性失活的皮肤中Na +的积累大约在雌性大鼠中为DeltaSKNa +的66％，在雄性可育大鼠中为82％，但是在饲喂8％NaCl的OVX大鼠中没有渗透性的Na +积累。我们得出的结论是，皮肤是一种无渗透活性的Na +储集层，当饮食中的NaCl过量时，会累积Na +。 OVX导致SD大鼠渗透性非活性Na +储存的获得性减少，尽管相对于体重而言Na +含量降低，这也使大鼠易于过剩。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号