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首页> 外文期刊>American Journal of Physiology >Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids.
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Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids.

机译：青春期瘦素水平的性别差异与皮下脂肪库和性类固醇有关。

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摘要

Little is known about the influence of adiposity and hormone release on leptin levels in children and adolescents. We utilized criterion methods to examine the relationships among sex steroids, body composition (4 compartment), abdominal visceral and subcutaneous fat (magnetic resonance imagery), total subcutaneous fat (sum of 9 skinfolds), energy expenditure (doubly labeled water), aerobic fitness, and serum leptin levels in prepubertal and pubertal boys (n = 16; n = 13) and girls (n = 12; n = 15). The sum of skinfolds accounted for more variance in leptin levels of all girls [coefficient of determination (R2) = 0.70, P < 0.001] and all boys (R2 = 0.60, P < 0.001) than the total fat mass (girls, R2 = 0.52, P < 0.001; boys, R2 = 0.23, P < 0.001). Total energy expenditure, corrected for the influence of fat-free mass, correlated inversely with leptin (R2 = 0.18, P = 0.02). Gender differences in leptin disappeared when corrected for sex steroid levels or the combination of adiposity and energy expenditure. In multiple regression, the sum of skinfolds and free testosterone and estrogen levels accounted for 74% of the variance in leptin levels. We conclude that serum leptin levels are positively related to subcutaneous adiposity but negatively related to androgen levels. Energy expenditure may be negatively related to leptin levels by reduction of the adiposity, or a common genetic factor may influence both the activity and serum leptin levels.
机译：关于肥胖和激素释放对儿童和青少年瘦素水平的影响知之甚少。我们使用标准方法来检查性类固醇，身体成分（4个隔室），腹部内脏和皮下脂肪（磁共振成像），皮下总脂肪（9个皮褶的总和），能量消耗（加双倍水），有氧健身之间的关系。和青春期前和青春期男孩（n = 16; n = 13）和女孩（n = 12; n = 15）的血清瘦素水平。皮褶的总和比所有脂肪量（女孩，R2 =）的所有女孩（测定系数（R2）= 0.70，P <0.001）和所有男孩（R2 = 0.60，P <0.001）的瘦素水平差异更大。 0.52，P <0.001;男孩，R2 = 0.23，P <0.001）。经无脂肪物质影响校正的总能量消耗与瘦素成反比（R2 = 0.18，P = 0.02）。校正性类固醇水平或肥胖与能量消耗的组合后，瘦素的性别差异消失。在多元回归中，皮褶和游离睾丸激素及雌激素水平的总和占瘦素水平差异的74％。我们得出结论，血清瘦素水平与皮下脂肪呈正相关，而与雄激素水平呈负相关。能量消耗可能通过减少肥胖而与瘦素水平负相关，或者常见的遗传因素可能影响活性和血清瘦素水平。

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