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首页> 外文期刊>American Journal of Physiology >Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats.
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Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats.

机译：膳食补充2-脱氧-D-葡萄糖可改善大鼠的心血管和神经内分泌应激适应性。

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摘要

Dietary restriction and physical exercise can enhance stress resistance and reduce the risk of cardiovascular disease. We investigated the effects of dietary supplementation with 2-deoxy-d-glucose (2-DG), a glucose analog that limits glucose availability at the cellular level, on cardiovascular and neuroendocrine responses to stress in rats. Young adult male Sprague-Dawley rats were implanted with telemetry probes to monitor blood pressure (BP), heart rate, body temperature, and body movements. These variables were measured at designated times during a 6-mo period in rats fed control and 2-DG-supplemented (0.4% 2-DG, fed ad libitum on a schedule of 2 days on the diet and 1 day off the diet) diets during unperturbed conditions and during and after immobilization stress or cold-water swim stress. Rats fed the 2-DG diet exhibited significant reductions in resting BP, attenuated BP responses during stress, and accelerated recovery to baseline after stress. Plasma concentrations of ACTH and corticosterone were elevated under nonstress conditions in rats fed the 2-DG diet and exhibited differential responses to single (enhanced response) and multiple (reduced response) stress sessions compared with rats fed control rat chow ad libitum. The 2-DG diet improved glucose metabolism, as indicated by decreased concentrations of blood glucose and insulin under nonstress conditions, but glucose and insulin responses to stress were maintained. We conclude that improvements in some cardiovascular risk factors and stress adaptation in rats maintained on a 2-DG-supplemented diet are associated with reduced neuroendocrine responses to the stressors.
机译：饮食限制和体育锻炼可以增强抵抗力，并降低患心血管疾病的风险。我们调查了饮食中添加2-脱氧-d-葡萄糖（2-DG）（一种在葡萄糖水平上限制葡萄糖水平的葡萄糖类似物）对大鼠心血管和神经内分泌应激反应的影响。将成年雄性Sprague-Dawley大鼠植入遥测探针，以监测血压（BP），心率，体温和身体运动。这些变量是在6个月的指定时间测量的，这些大鼠在6个月内喂食对照和补充2-DG（0.4％2-DG，按饮食2天和饮食1天的计划随意进食）的大鼠在不受干扰的条件下以及在固定压力或冷水游泳压力期间和之后。饲喂2-DG饮食的大鼠表现出静息BP显着降低，应激期间BP反应减弱以及应激后加速恢复至基线。与随意喂食对照大鼠的大鼠相比，在以2-DG饮食喂养的大鼠中，在非应激条件下血浆ACTH和皮质酮的浓度升高，并且对单次（增强反应）和多次（降低反应）应激反应表现出不同的反应。 2-DG饮食改善了葡萄糖代谢，这在非应激条件下降低了血糖和胰岛素的浓度，但葡萄糖和胰岛素对应激的反应得以维持。我们得出结论，在补充2-DG饮食的大鼠中某些心血管危险因素的改善和应激适应与神经内分泌对应激源的反应减少有关。

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