• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Lymphocyte transfer in streptozotocin-induced diabetes: adhesion of donor cells to islet endothelium.
【24h】

Lymphocyte transfer in streptozotocin-induced diabetes: adhesion of donor cells to islet endothelium.

机译：链脲佐菌素诱发的糖尿病中的淋巴细胞转移：供体细胞与胰岛内皮的粘附。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The interaction between intravenously transferred lymphocytes derived from spleens of multiple low-dose streptozotocin-diabetic mice with islet, exocrine pancreatic, and gastric mucosal endothelium of nondiabetic recipient mice was investigated by in vivo microscopy. Donor lymphocytes were stained with acridine red in vitro. The adoptive transfer of these cells from diabetic donor animals resulted in significantly increased lymphocyte rolling (4.46 +/- 1.32%, P < 0.05) and adhesion (3.86 +/- 1.04%, P < 0.05) in islets of nondiabetic recipients that had been pretreated with a single subdiabetogenic dose of streptozotocin. No increased endothelial interaction was noted in nonpretreated recipients or in experiments with nondiabetic donors. Rolling (1.19 +/- 0.61 to 2.71 +/- 0.62%) and adhesion (0.61 +/- 0.33 to 2.80 +/- 0.97%) of donor lymphocytes were low in exocrine pancreatic and gastric mucosal control tissue. It is concluded that, in this animal model, lymphocytes from diabetic donors interact preferentially with recipient islet endothelium. However, additional stimulation of recipient islet endothelium by exogenous factors is necessary to enable transferred cells to adhere to pancreatic islets.
机译：通过体内显微镜研究了多只低剂量链脲佐菌素-糖尿病小鼠的胰岛，外分泌胰腺和胃黏膜内皮的脾脏静脉注射淋巴细胞之间的相互作用。供体淋巴细胞在体外用a啶红染色。这些来自糖尿病供体动物的细胞的过继转移导致非糖尿病受体胰岛的淋巴细胞滚动显着增加（4.46 +/- 1.32％，P <0.05）和粘附（3.86 +/- 1.04％，P <0.05）。用单次糖尿病致死剂量的链脲佐菌素预处理。在未预处理的接受者或非糖尿病供体的实验中，未发现内皮相互作用增加。在外分泌胰腺和胃黏膜对照组织中，供体淋巴细胞的滚动（1.19 +/- 0.61至2.71 +/- 0.62％）和粘附（0.61 +/- 0.33至2.80 +/- 0.97％）低。结论是，在该动物模型中，来自糖尿病供体的淋巴细胞优先与受体胰岛内皮相互作用。然而，外源性因子对受体胰岛内皮的额外刺激是必需的，以使转移的细胞能够粘附于胰岛。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号