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首页> 外文期刊>American Journal of Physiology >Increases in CSF (Na+) precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet.
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Increases in CSF (Na+) precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet.

机译：高盐饮食的Dahl S大鼠和SHR的CSF（Na +）升高先于血压升高。

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In Dahl salt-sensitive (S) and salt-resistant (R) rats, and spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, at 5-6 wk of age, a cannula was placed in the cisterna magna, and cerebrospinal fluid (CSF) was withdrawn continuously at 75 microl/12 h. CSF was collected as day- and nighttime samples from rats on a regular salt intake (0.6% Na+; R-Na) and then on a high salt intake (8% Na+; H-Na). In separate groups of rats, the abdominal aorta was cannulated and blood pressure (BP) and heart rate (HR) measured at 10 AM and 10 PM, with rats first on R-Na and then on H-Na. On H-Na, CSF [Na+] started to increase in the daytime of day 2 in Dahl S rats and of day 3 in SHR. BP and HR did not rise until day 3 in Dahl S rats and day 4 in SHR. In Dahl R and WKY rats, high salt did not change CSF [Na+], BP, or HR. In a third set of Dahl S rats, sampling of both CSF and BP was performed in each individual rat. Again, significant increases in CSF [Na+] were observed 1-2 days earlier than the increases in BP and HR. In a fourth set of Dahl S rats, BP and HR were recorded continuously by means of radiotelemetry for 5 days on R-Na and 8 days on H-Na. On H-Na, BP (but not HR) increased first in the nighttime of day 2. In another set of Dahl S rats, intracerebroventricular infusion of antibody Fab fragments binding ouabain-like compounds (OLC) with high affinity prevented the increase in BP and HR by H-Na but further increased CSF [Na+]. Finally, in Wistar rats on H-Na, intracerebroventricular infusion of ouabain increased BP and HR but decreased CSF [Na+]. Thus, in both Dahl S and SHR on H-Na, increases in CSF [Na+] preceded the increases in BP and HR, consistent with a primary role of increased CSF [Na+] in the salt-induced hypertension. An increase in brain OLC in response to the initial increase in CSF [Na+] appears to attenuate further increases in CSF [Na+] but at the "expense" of sympathoexcitation and hypertension.
机译：在Dahl盐敏感性（S）和抗盐（R）大鼠以及自发性高血压大鼠（SHR）和Wistar-Kyoto（WKY）大鼠中，在5-6周龄时，将一根插管放置在大水罐中，并以75微升/ 12小时连续抽出脑脊液（CSF）。从大鼠中定期摄入盐（0.6％Na +; R-Na），然后以高盐摄入（8％Na +; H-Na）作为昼夜样品从脑中收集CSF。在单独的大鼠组中，将腹主动脉插管，并在上午10点和晚上10点测量血压（BP）和心率（HR），大鼠首先在R-Na上，然后在H-Na上。在H-Na上，Dahl S大鼠第2天和SHR第3天CSF [Na +]开始增加。直到Dahl S大鼠第3天和SHR第4天，BP和HR才升高。在Dahl R和WKY大鼠中，高盐不会改变CSF [Na +]，BP或HR。在第三组Dahl S大鼠中，在每只大鼠中都进行了CSF和BP的采样。再次，在BP和HR升高之前1-2天观察到CSF [Na +]显着升高。在第四组Dahl S大鼠中，通过无线电遥测法在R-Na上连续记录5天，在H-Na上连续记录8天。在H-Na上，血压在第2天夜间升高（但不是HR）。在另一组Dahl S大鼠中，脑室内以高亲和力结合哇巴因样化合物（OLC）的抗体Fab片段脑室输注阻止了BP的升高H-Na和HR，但脑脊液[Na +]进一步增加。最后，在Wistar大鼠的H-Na溶液中，脑室输注哇巴因增加BP和HR，但降低CSF [Na +]。因此，在H-Na的Dahl S和SHR中，CSF [Na +]的升高先于BP和HR的升高，这与盐诱导的高血压中CSF [Na +]升高的主要作用一致。响应于CSF [Na +]最初增加而引起的大脑OLC的增加似乎会减弱CSF [Na +]的进一步增加，但以交感神经兴奋和高血压为“代价”。

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