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首页> 外文期刊>American Journal of Physiology >Behavioral and endocrine traits of obesity-prone and obesity-resistant rats on macronutrient diets.
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Behavioral and endocrine traits of obesity-prone and obesity-resistant rats on macronutrient diets.

机译：大量营养饮食对易肥胖和抵抗肥胖大鼠的行为和内分泌特征。

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Patterns of eating behavior, body weight gain, and hormone changes were examined in normal-weight albino Sprague-Dawley rats on macronutrient diets. These diets consisted of either three separate jars with pure macronutrients, fat, carbohydrate and protein, from which to choose, or a single diet with different concentrations of fat and carbohydrate. Similar patterns on the choice-diet and single-diet paradigms were observed. During the first 7-10 days on these diets but not subsequently, the rats consuming a fat-rich diet exhibit significant hyperphagia, an increase in both total and fat intake that produces higher body weight gain. Compared with a 10% fat diet, a 30% fat diet is associated with a decline in insulin and corticosterone (CORT) levels, whereas a 60% fat diet produces an increase in circulating glucose. Levels of glucose are positively correlated with fat intake, and together these measures are consistently related to body fat. These relationships are most strongly expressed in rats that consume a fat-rich diet with >30% fat. Whereas insulin levels are also positively related to body fat, CORT is inversely related in these normal-weight subjects. In animals consuming a high-fat diet, a clear separation can be seen between "obesity-prone" (OP) rats with 100% greater body fat than "obesity-resistant" (OR) rats. The OP rats, which consume 15% more total calories, have significantly higher insulin and glucose levels. In animals that consume a diet with >30% fat, it is the OP but not the OR rats that exhibit a positive relation between fat intake, glucose levels, and body fat and reveal an additional association between carbohydrate intake, insulin, and body fat. Thus these rats on macronutrient diets exhibit distinct traits that relate behavior to hormone disturbances and adiposity and distinguish subjects that are prone vs. resistant to obesity.
机译：在正常体重的白化病Sprague-Dawley大鼠中，通过大量营养饮食检查了饮食行为，体重增加和激素变化的模式。这些饮食包括三个单独的罐子，其中包含纯净的大量营养素，脂肪，碳水化合物和蛋白质，可以从中选择，也可以是单一饮食，其中的脂肪和碳水化合物的浓度不同。在选择饮食和单一饮食范式上观察到相似的模式。在使用这些饮食的前7-10天中，但随后没有，食用高脂饮食的大鼠表现出明显的食欲亢进，总摄入量和脂肪摄入均增加，从而导致体重增加。与10％的脂肪饮食相比，30％的脂肪饮食会降低胰岛素和皮质酮（CORT）的水平，而60％的脂肪饮食则会增加循环葡萄糖。葡萄糖水平与脂肪摄入呈正相关，并且这些指标始终与体内脂肪相关。在食用脂肪含量大于30％的高脂肪饮食的大鼠中，这些关系最明显。尽管胰岛素水平也与体内脂肪呈正相关，但在这些体重正常的受试者中CORT呈负相关。在食用高脂饮食的动物中，与“抗肥胖”（OR）大鼠相比，其体脂高100％的“易肥胖”（OP）大鼠之间可以清楚地分离。消耗总卡路里多15％的OP大鼠的胰岛素和葡萄糖水平明显更高。在饮食中脂肪> 30％的动物中，OP大鼠而不是OR大鼠在脂肪摄入，葡萄糖水平和体脂之间表现出正相关，并显示碳水化合物摄入，胰岛素和体脂之间存在其他关联。因此，这些采用大量营养饮食的大鼠表现出与行为有关的独特特征，这些行为与激素紊乱和肥胖有关，并区分了容易肥胖的人和对肥胖具有抵抗力的人。

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