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首页> 外文期刊>American Journal of Physiology >Role for parathyroid hormone in mechanical responsiveness of rat bone.
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Role for parathyroid hormone in mechanical responsiveness of rat bone.

机译：甲状旁腺激素在大鼠骨骼机械反应中的作用。

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摘要

We investigated the relationship between parathyroid hormone (PTH) and mechanical stimulation in mechanically induced osteogenesis. In normal rats, mechanical stimulation of the eight caudal vertebra induced an osteogenic response. This was augmented by a single injection of human PTH-(1-34) 30-45 min before loading. No osteogenic response was seen in thyroparathyroidectomized (TPTX) rats; the osteogenic response was restored by a single injection of PTH before stimulation, suggesting that physiological levels of PTH are necessary for the mechanical responsiveness of bone. c-fos expression was detected only in the osteocytes of those rats that were both mechanically stimulated and given PTH. This suggests that PTH supports mechanically induced osteogenesis by sensitizing either the strain-sensing mechanism itself or early responses of bone to strain-generated signals. The osteogenic response was not augmented by two further daily injections of PTH and was not seen in TPTX rats in which PTH administration was started 3 days after loading. These results reveal a major role for PTH in the mechanical responsiveness of rat bone.
机译：我们调查了甲状旁腺激素（PTH）和机械刺激在机械诱导的成骨中的关系。在正常大鼠中，对八尾椎的机械刺激引起了成骨反应。在装载前30-45分钟，单次注射人PTH-（1-34）可以增强这种作用。在甲状腺副甲状腺切除（TPTX）大鼠中未观察到成骨反应。通过在刺激前单次注射PTH可恢复成骨反应，这表明PTH的生理水平对于骨骼的机械反应性是必需的。仅在机械刺激和给予PTH的那些大鼠的骨细胞中检测到c-fos表达。这表明PTH通过使应变感应机制本身或骨骼对应变生成信号的早期响应敏感来支持机械诱导的成骨作用。每天再注射两次PTH不会增强成骨反应，在TPTX大鼠中也看不到成骨反应，在TPTX大鼠中，负荷后3天开始施用PTH。这些结果揭示了PTH在大鼠骨骼机械反应中的主要作用。

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