• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Directionality of coupling of physiological subsystems: age-related changes of cardiorespiratory interaction during different sleep stages in babies.
【24h】

Directionality of coupling of physiological subsystems: age-related changes of cardiorespiratory interaction during different sleep stages in babies.

机译：生理子系统耦合的方向性：婴儿在不同睡眠阶段心肺相互作用的年龄相关变化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Activity of many physiological subsystems has a well-expressed rhythmic character. Often, a dependency between physiological rhythms is established due to interaction between the corresponding subsystems. Traditional methods of data analysis allow one to quantify the strength of interaction but not the causal interrelation that is indispensable for understanding the mechanisms of interaction. Here we present a recently developed method for quantification of coupling direction and apply it to an important problem. Namely, we study the mutual influence of respiratory and cardiovascular rhythms in healthy newborns within the first 6 mo of life in quiet and active sleep. We find an age-related change of the coupling direction: the interaction is nearly symmetric during the first days and becomes practically unidirectional (from respiration to heart rhythm) at the age of 6 mo. Next, we show that the direction of interaction is mainly determined by respiratory frequency. If the latter is less than approximately 0.6 Hz, the interaction occurs dominantly from respiration to heart. With higher respiratory frequencies that only occur at very young ages, the dominating direction is less pronounced or even abolished. The observed dependencies are not related to sleep stage, suggesting that the coupling direction is determined by system-inherent dynamical processes, rather than by functional modulations. The directional analysis may be applied to other interacting narrow band oscillatory systems, e.g., in the central nervous system. Thus it is an important step forward in revealing and understanding causal mechanisms of interactions.
机译：许多生理子系统的活动具有良好表达的节律特征。通常，由于相应子系统之间的相互作用，在生理节律之间建立了依赖性。传统的数据分析方法允许量化相互作用的强度，但不能量化因果关系，而因果关系是理解相互作用机理必不可少的。在这里，我们提出了一种最新开发的耦合方向量化方法，并将其应用于重要问题。即，我们研究了安静和积极睡眠中生命的最初6个月内健康新生儿的呼吸和心血管节律的相互影响。我们发现了与年龄相关的耦合方向变化：交互作用在开始的几天中几乎是对称的，并且在6 mo时几乎变成单向的（从呼吸到心律）。接下来，我们表明相互作用的方向主要由呼吸频率决定。如果后者小于约0.6 Hz，则相互作用主要发生在呼吸到心脏。由于只有在很小的时候才会出现较高的呼吸频率，因此主要方向不太明显甚至被取消。观察到的依赖性与睡眠阶段无关，这表明耦合方向是由系统固有的动力学过程而不是功能调制确定的。方向分析可以应用于例如中枢神经系统中的其他相互作用的窄带振荡系统。因此，这是揭示和理解相互作用的因果机制的重要一步。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号