...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current therapeutic research, clinical and experimental. >Dexmedetomidine as an Adjunct to Epidural Analgesia After Abdominal Surgery in Elderly Intensive Care Patients: A Prospective, Double-Blind, Clinical Trial
【24h】

Dexmedetomidine as an Adjunct to Epidural Analgesia After Abdominal Surgery in Elderly Intensive Care Patients: A Prospective, Double-Blind, Clinical Trial

机译：右美托咪定作为老年重症监护患者腹部手术后硬膜外镇痛的辅助手段：一项前瞻性双盲临床试验

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The ideal postoperative analgesia management of elderly surgical patients in intensive care units (ICUs) is continually being investigated.OBJECTIVE: The purpose of this study was to assess the effectiveness and toler-ability of IV administration of dexmedetomidine as an adjunct to a low-dose epidural bupivacaine infusion for postoperative analgesia after abdominal surgery in elderly patients in the ICU.METHODS: ICU patients aged >70 years undergoing abdominal surgery were eligible for the study. A lumbar epidural catheter was inserted at the beginning of the surgery with no medication. On arrival at the ICU, the catheter was loaded with 0.25% bupivacaine 25 mg at the T8 to T10 sensory level, and a continuous infusion of 0.125% bupivacaine was started at 4 to 6 mL/h in combination with patient-controlled epidural analgesia (PCEA) of fentanyl (4 ug/bolus) for pain treatment. Patients in the treatment group received dexmedetomidine as an IV loading dose of 0.6mug/kg for 30 minutes followed bycontinuous infusion at 0.2mug/kg h~(-1). Patients in the control group were not administered dexmedetomidine. The effectiveness of the pain relief was determined using a visual analog scale (VAS) (0 = no pain to 10 = worst pain imaginable) at rest. VAS score, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure, and arterial blood gases were monitored periodically for 24 hours after surgery. If required, tenoxicam (20-mg IV bolus) was used to ensure a VAS score of <3. The number of times PCEA and tenoxicam were administered and the occurrence of adverse events (AEs) were also recorded.RESULTS: Sixty patients (34 men, 26 women; mean [SD] age, 75.96 [4.25] years; mean {SD} weight, 74.13 {10.62} kg) were included in the study, VAS scores were significantly lower in the dexmedetomidine group compared with the control group at hours 1, 2, and 12 (VAS {hour 1}: 2.8 {0.4}, P < 0.001; VAS {hour 2]: 2.7 {0.5], P < 0.001; and VAS {hour 12}: 0.9 {0.7}, P = 0.044). The mean number of administrations of fentanyl via PCEA was significantly greater in the control group compared with the dexmedeu> midine group (2.20 vs 6.63 times; P < 0.001).
机译：背景：不断研究重症监护病房（ICU）中老年外科手术患者的理想术后镇痛管理方法。目的：本研究的目的是评估静脉注射右美托咪定作为低剂量辅助药物的有效性和耐受性ICU老年患者腹部手术后大剂量硬膜外布比卡因输注术后镇痛方法：方法：≥70岁接受腹部手术的ICU患者符合此项研究的条件。在手术开始时不使用药物就插入了腰椎硬膜外导管。到达ICU时，在T8至T10感官水平向导管加载0.25％布比卡因25 mg，并开始以4至6 mL / h的速度连续输注0.125％布比卡因，并结合患者控制的硬膜外镇痛（芬太尼（PCA）（4 ug /次）用于疼痛治疗。治疗组的患者在静脉内负荷剂量为0.6mug / kg的右美托咪定30分钟后，以0.2mug / kg h〜（-1）连续输注。对照组患者未给予右美托咪定。使用视觉模拟量表（VAS）（0 =无疼痛至10 =可以想象的最严重疼痛）确定缓解疼痛的效果。术后24小时定期监测VAS评分，心率（HR），收缩压（SBP），舒张压和动脉血气。如果需要，使用替诺昔康（20毫克静脉推注）以确保VAS评分<3。结果：记录了60例患者（男34例，女26例;平均[SD]年龄：75.96 [4.25]岁;平均{SD}体重），并记录了PCEA和替诺昔康的使用次数，并记录了不良事件（AEs）的发生。 ，74.13 {10.62}公斤）包括在内，右美托咪定组的VAS评分在第1、2和12小时比对照组明显降低（VAS {小时1}：2.8 {0.4}，P <0.001 ; VAS {小时2]：2.7 {0.5]，P <0.001; VAS {小时12}：0.9 {0.7}，P = 0.044）。对照组中芬太尼通过PCEA的平均给药次数明显多于右旋米丁组（2.20比6.63倍; P <0.001）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号