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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Lidocaine for Prevention of Propofol Injection-Induced Pain: A Prospective, Randomized, Double-Blind, Controlled Study of the Effect of Duration of Venous Occlusion with a Tourniquet in Adults
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Lidocaine for Prevention of Propofol Injection-Induced Pain: A Prospective, Randomized, Double-Blind, Controlled Study of the Effect of Duration of Venous Occlusion with a Tourniquet in Adults

机译：利多卡因预防异丙酚注射引起的疼痛：成人止血带静脉闭塞持续时间影响的前瞻性，随机，双盲，对照研究

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BACKGROUND: Many patients experience pain on injection of propofol. The use of lidocaine to prevent propofol injection pain is common. The analgesic effect of pre-injected lidocaine has been found to increase when a tourniquet is used.OBJECTIVE: The aim of this study was to compare the effectiveness of various venous occlusion times with lidocaine analgesia to prevent pain during propofol injection.Methods: In this prospective, randomized, double-blind, controlled study, women aged 18 to 45 years, classified as American Society of Anesthesiologists physical status I or II, who were scheduled to undergo elective surgery under general anesthesia induced with propofol, were randomly assigned to 1 of 5 groups: group 1, 2% lidocaine 20 mg in saline in a total volume of 10 mL and no venous occlusion; group 2, 2% lidocaine 20 mg in saline in a total volume of 10 mL plus venous occlusion for 15 seconds; group 3, 2% lidocaine plus venous occlusion for 30 seconds; group 4, 2% lidocaine plus venous occlusion for 60 seconds; and group 5, saline 10 mL and no venous occlusion. When the first 25% of the calculated propofol dose was administered, patients were asked about propofol-induced pain using a verbal pain scale (0 = no pain; 1 = mild pain; 2 = moderate pain; and 3 = severe pain). All patients and the anesthesiologist who evaluated pain severity were blinded to the study preparation being used.RESULTS: The study comprised 100 women who were randomly divided into 5 groups of 20 patients each. Significantly more patients in group 5 (18 [90%} patients; P < 0.05) reported pain compared with the other treatment groups. In groups 2, 3, and 4, in which venous occlusion was applied, pain was reported during propofol injection in 6 (30%), 7 (35%), and 2 (10%) patients, respectively. The incidence of reported pain was significantly greater in group 1 (lidocaine without venous occlusion) than in group 4 (P < 0.05); however, the incidence of pain was similar in group 1 compared with groups 2 and 3.CONCLUSIONS: The present study found that pretreatment with lidocaine 20 mg with or without venous occlusion significantly reduced the incidence and the severity of pain during the injection of propofol when compared with the group with no venous occlusion administered saline. In addition, pretreatment with lidocaine 20 mg plus venous occlusion for 60 seconds significantly reduced the incidence of propofol-induced pain compared with lidocaine without venous occlusion.
机译：背景：许多患者在注射异丙酚时会感到疼痛。通常使用利多卡因预防丙泊酚注射疼痛。目的：使用止血带时，预注射利多卡因的镇痛作用会增强。目的：本研究的目的是比较各种静脉阻塞时间与利多卡因镇痛的效果，以预防异丙酚注射时的疼痛。前瞻性，随机，双盲，对照研究，年龄在18至45岁，被定为美国麻醉医师协会I或II身分的女性，这些女性计划在异丙酚引起的全身麻醉下接受择期手术，被随机分配至1个5组：第1组，在生理盐水中2％利多卡因20 mg，总体积为10 mL，无静脉阻塞;第2组，在盐水中2％利多卡因20 mg，总体积为10 mL，静脉阻塞15秒;第3组，2％利多卡因加静脉阻塞30秒;第4组，2％利多卡因加静脉阻塞60秒;第5组，生理盐水10 mL，无静脉阻塞。最初计算的丙泊酚剂量的25％给药后，使用言语疼痛量表（0 =无疼痛; 1 =轻度疼痛; 2 =中度疼痛; 3 =严重疼痛）询问患者丙泊酚引起的疼痛。所有评估疼痛严重程度的患者和麻醉师都不知道所使用的研究准备。结果：该研究包括100名妇女，她们被随机分为5组，每组20名患者。与其他治疗组相比，第5组中有更多的患者报告疼痛（18 [90％}名患者; P <0.05）。在第2、3和4组中，采用静脉闭塞的患者，在异丙酚注射期间分别有6（30％），7（35％）和2（10％）的患者报告了疼痛。第1组（无静脉阻塞的利多卡因）报告的疼痛发生率明显高于第4组（P <0.05）;然而，与第2组和第3组相比，第1组的疼痛发生率相似。结论：本研究发现，在有或没有静脉闭塞的情况下用20 mg利多卡因进行预处理可显着降低丙泊酚注射时的疼痛发生率和严重程度。与没有静脉闭塞的组比较。此外，与没有静脉阻塞的利多卡因相比，用20 mg利多卡因加静脉阻塞进行60秒钟的预处理可以显着降低异丙酚引起的疼痛发生率。

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