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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Preventing Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind Study
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Preventing Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind Study

机译：预防腹腔镜胆囊切除术后的恶心和呕吐：一项前瞻性，随机，双盲研究

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BACKGROUND: Postoperative nausea and vomiting (PONV) are potential complications in patients after laparoscopic cholecystectomy (LC). Combination anti-emetic therapy often is effective for preventing PONV in patients undergoing LC, and combinations of antiemetics targeting different sites of activity may be more effective than monotherapy.OBJECTIVE: The aim of this study was to compare the administration of a subhypnotic dose of propofol combined with dexamethasone with one of propofol combined with metoclopramide to prevent PONV after LC.METHODS: Sixty adult patients scheduled for LC were randomly assigned to 1 of 2 treatment groups. The patients in group 1 received 0.5 mg/kg propofol plus 8 mg dexamethasone, and those in group 2 received 0.5 mg/kg propofol plus 0.2 mg/kg metoclopramide. The number of patients experiencing nausea and vomiting at 0 to 4, 4 to 12, and 12 to 24 hours postoperatively and as well as additional use of rescue antiemetics were recorded.RESUUTS: The total PONV rates up to 24 hours postanesthesia were 23.3% and 50% for group 1 and group 2, respectively. Comparisons of the data revealed that at 0 to 4 hours, the number of patients experiencing vomiting was 6 (20%) in group 1 andl4 (46.7%) in group 2 (P = 0.028). The frequency of vomiting in group 1 was significantly lower than that for group 2 (P = 0.028), and the rate of rescue antiemetic use in group 2 was higher than that in group 1 (20% vs 46.7%; P -0.028). In the evaluation of PONV based on the nausea and vomiting scale scores, the mean PONV score was 0.4 (0.2) in group 1 compared with 1.0 (0.2) in group 2 (P = 0.017). There were no significant differences between the values at 4 to 12 hours and at 12 to 24 hours. The frequency of adverse reactions (respiratory depression: 1.3%, 1.3%; laryngospasm: 1.3%, 0%; cough: 1.3%, 0%; hiccup: 1.3%, 0%;) was not significantly different in the 2 groups.CONCLUSIONS: Administration of a subhypnotic dose of 0.5 mg/kg propofol plus 8 mg dexamethasone...
机译：背景：腹腔镜胆囊切除术（LC）术后患者的恶心和呕吐（PONV）是潜在的并发症。联合止吐药通常可有效预防LC患者的PONV，针对不同活动部位的止吐药联合使用可能比单一疗法更有效。目的：本研究的目的是比较亚催眠剂量的异丙酚的给药方法方法：将60例接受LC治疗的成年患者随机分配至2个治疗组中的1个。第一组的患者接受0.5 mg / kg异丙酚加8 mg地塞米松，第二组的患者接受0.5 mg / kg异丙酚加0.2 mg / kg甲氧氯普胺。记录术后0到4、4到12，和12到24小时出现恶心和呕吐的患者人数，并记录了额外使用抢救止吐药的情况。麻醉后24小时，PONV的总发生率为23.3％，第一组和第二组分别为50％。数据比较显示，在0至4小时时，第1组的呕吐患者数为6（20％），第2组的为14（46.7％）（P = 0.028）。第1组的呕吐频率明显低于第2组（P = 0.028），第2组的止吐使用率高于第1组（20％比46.7％; P -0.028）。在根据恶心和呕吐量表评分对PONV进行评估时，第1组的平均PONV评分为0.4（0.2），而第2组的平均PONV评分为1.0（0.2）（P = 0.017）。在4至12小时和12至24小时的值之间没有显着差异。两组的不良反应发生频率（呼吸抑制：1.3％，1.3％;喉痉挛：1.3％，0％;咳嗽：1.3％，0％;打cup：1.3％，0％;）在两组中无显着差异。 ：给予0.5 mg / kg异丙酚亚催眠剂量加8 mg地塞米松...

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