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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Clinical Analysis of Chinese Patients With Rheumatoid Arthritis Treated With Leflunomide and Methotrexate Combined With Different Dosages of Glucocorticoid
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Clinical Analysis of Chinese Patients With Rheumatoid Arthritis Treated With Leflunomide and Methotrexate Combined With Different Dosages of Glucocorticoid

机译：来氟米特和甲氨蝶呤联合不同剂量糖皮质激素治疗中国类风湿关节炎的临床分析

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OBJECTIVE: To analyze the safety of combined leflunomide (LEF), methotrexate (MTX), and glucocorticoid (GC) therapy, we investigated the adverse effects of such combination therapy in patients with early active rheumatoid arthritis (RA).METHODS: Two hundred sixty-six patients with RA who were receiving LEF and MTX therapy were randomly assigned to 3 groups, as follows: group 1 received no GC, group 2 received 7.5 mg prednisone, and group 3 received 15 mg prednisone. Adverse effects were analyzed using the x~2 test at week 4 or the Fisher exact test at week 12.RESULTS: Patients in group 1 had a higher incidence of skin rash, oral ulcers, leukopenia, and liver damage than did those in groups 2 and 3 (all, P <= 0.05). However, the rates of osteoporosis, diabetes, hyperlipidemia, and hypertension in group 3 were statistically higher than in groups 1 and 2 (P <= 0.05).CONCLUSION: In the treatment of RA, the incidence of skin rash, liver dysfunction, and oral ulcers may be decreased with combination therapy using LEF, MTX, and 7.5 mg prednisone, and blood pressure, blood glucose concentration, and bone density are not increased. Most important, 7.5 mg prednisone was synergistic with LEF and MTX, and such combination therapy could be a useful option as initial treatment of early active RA.
机译：目的：为了分析来氟米特（LEF），甲氨蝶呤（MTX）和糖皮质激素（GC）联合治疗的安全性，我们研究了这种联合治疗对早期活动性类风湿关节炎（RA）患者的不良反应。方法：260将接受LEF和MTX治疗的6例RA患者随机分为3组：第1组未接受GC，第2组接受了7.5 mg泼尼松，第3组接受了15 mg泼尼松。使用第4周的x〜2检验或第12周的Fisher精确检验分析不良反应。结果：第1组患者的皮疹，口腔溃疡，白细胞减少症和肝损伤的发生率高于第2组和3（所有，P <= 0.05）。但是，第3组的骨质疏松，糖尿病，高脂血症和高血压的发生率在统计学上高于第1和第2组（P <= 0.05）。结论：在RA的治疗中，皮疹，肝功能异常和使用LEF，MTX和7.5 mg泼尼松联合治疗可减少口腔溃疡，并且血压，血糖浓度和骨密度不会增加。最重要的是，7.5 mg泼尼松与LEF和MTX协同作用，这种联合治疗可能是早期治疗早期活动性RA的有用选择。

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