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首页> 外文期刊>Current therapeutic research, clinical and experimental. >The Effect of Tamsulosin on Pain and Clearance According to Ureteral Stone Location After Shock Wave Lithotripsy
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The Effect of Tamsulosin on Pain and Clearance According to Ureteral Stone Location After Shock Wave Lithotripsy

机译：坦波罗辛对冲击波碎石术后输尿管结石位置的疼痛和清除的影响

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Background: Medical expulsion therapy has shown encouraging results in facilitating spontaneous clearance of ureteral stones after extracorporeal shock wave lithotripsy. However, no other study has yet determined the benefit of medical expulsion therapy for stones in different ureteral locations. Objective: The aim of the study was to evaluate tamsulosin as adjunctive therapy to extracorporeal shock wave lithotripsy (SWL) in terms of pain clearance of stones in the upper, middle, and lower ureter. Methods: Between June 2008 and July 2011, patients with a solitary ureteral stone that was >6 mm up to 15 mm and located in the upper, middle, or lower ureter undergoing SWL were evaluated. The patients were randomly allocated to a conservative treatment (group 1) and a tamsulosin treatment group (group 2). Administration of the drug was started immediately after SWL and was continued for a maximum of 28 days. Patients were evaluated for stone clearance, time to stone clearance, and number of SWL sessions. The pain intensity was evaluated by visual analog scale.Results: There were 64 patients in the control group and 59 in the tamsulosin group. The average stone sizes were 10.70 (3.20) mm and 11.40 (3.01) mm (P = 0.24). Group 1 and group 2 received 2507 (984) and 2759 (775) shock waves (P = 0.86), 1.53 (0.8) and 1.49 (0.75) sessions (P = 0.85), respectively. Mean visual analog scale scores and times to clearance were 3.81 (2.74) and 2.73 (2.28) (P = 0.00) and 12.59 (8.63) days and 8.34 (7.60) days (P = 0.00), respectively, for all stones in groups 1 and 2. Only the clearance time of upper ureteral stones between groups showed statistical significance (13.54 [8.32] days vs 7.10 [6.40] days; P = 0.00). Conclusions: Tamsulosin may help in the treatment of all ureteral stones after SWL, particularly stones in the upper ureter, with a shorter time to clearance and less need for analgesic drugs.
机译：背景：驱逐治疗在体外冲击波碎石术后自发清除输尿管结石方面显示出令人鼓舞的结果。但是，尚无其他研究确定针对不同输尿管部位结石的药物驱逐治疗的益处。目的：本研究的目的是根据输尿管上，中，下输尿管结石的疼痛清除情况，评估坦索罗辛作为体外冲击波碎石术（SWL）的辅助治疗方法。方法：在2008年6月至2011年7月之间，对接受了SWL的孤立输尿管结石（> 6 mm至15 mm）位于上，中或下输尿管的患者进行了评估。将患者随机分为保守治疗组（第1组）和坦索罗辛治疗组（第2组）。 SWL后立即开始给药，最多持续28天。对患者的结石清除率，清除结石的时间和SWL次数进行了评估。结果：对照组64例，坦索罗辛组59例。平均石材尺寸为10.70（3.20）毫米和11.40（3.01）毫米（P = 0.24）。第1组和第2组分别收到2507（984）和2759（775）冲击波（P = 0.86），1.53（0.8）和1.49（0.75）会话（P = 0.85）。第一组的所有结石的平均视觉模拟量表评分和清除时间分别为3.81（2.74）和2.73（2.28）（P = 0.00）和12.59（8.63）天和8.34（7.60）天（P = 0.00） 2.仅两组之间的上输尿管结石清除时间具有统计学意义（13.54 [8.32]天vs 7.10 [6.40]天; P = 0.00）。结论：坦索罗辛可能有助于治疗SWL后的所有输尿管结石，特别是上输尿管结石，清除时间更短，对镇痛药的需求更少。

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