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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Is There an Association Between Synovial CD30+ T Lymphocyte Count and Chondral Lesion Depth?
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Is There an Association Between Synovial CD30+ T Lymphocyte Count and Chondral Lesion Depth?

机译：滑膜CD30 + T淋巴细胞计数与软骨病变深度之间有关联吗？

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Background: Exact role of the inflammation in osteoarthritis is still unclear, but it is thought to originate from synovitis due to micro-crystals or breakdown products of the cartilage.Objective: To determine the effect of CD30+ T lymphocytes on the development of osteoarthritis by comparing the lesion depth and synovial CD30 I count in patients with chondral lesions undergoing knee joint arthroscopy.Design: A total of 79 patients with chondral lesions detected during arthroscopy were categorized in 4 different groups based on chondral lesion classification. CD30-r lymphocyte counts were calculated using flow cytometry on synovial fluid samples obtained at the time of initial entrance into the joint and compared between the groups. In addition, biopsy samples obtained from the suprapatellar bursa were stained for histologic examination to identify existence of CD30+ lymphocytes in the synovium. Results: Although there were no significant differences between the first 3 groups in terms of synovial fluid CD30+ lymphocyte counts, patients in Group IV had significantly higher counts (6.2 8 [2.48] vs 2.51 [1.84], 2.97 [2.40], and 3.80 [2.07], respectively; P < 0.05). Except for a single patient with a Grade III chondral lesion, there were no cases of CD30 positivity in synovial tissue. Also there was a correlation between CD30 levels and chondral lesion depth when controlled for age.Conclusions: Our results indicate higher CD30+ lymphocyte counts in patients with modified Outer-bridge Grade IV chondral lesions than in other groups. The origin of the CD30+ lymphocytes may not be the synovial tissue per se. Thus, it was hypothesized that the injured chondral tissues and the associated subchondral structures might have been the source of CD30+ lymphocytes with a possible influence on the development of osteoarthritis.
机译：背景：炎症在骨关节炎中的确切作用尚不清楚，但据认为是由于软骨的微晶体或分解产物引起的滑膜炎。目的：通过比较确定CD30 + T淋巴细胞对骨关节炎发展的影响设计：根据膝关节病变分类，将共79例关节镜检查中发现的软骨病变患者分为4个不同的组。使用流式细胞术对初次进入关节时获得的滑液样本计算CD30-r淋巴细胞计数，并在各组之间进行比较。此外，将从上睑滑囊获得的活检样品染色以进行组织学检查，以鉴定滑膜中是否存在CD30 +淋巴细胞。结果：尽管前3组滑膜液CD30 +淋巴细胞计数无明显差异，但IV组患者的滑膜CD30 +淋巴细胞计数显着更高（6.2 8 [2.48] vs 2.51 [1.84]，2.97 [2.40]和3.80 [ 2.07]; P <0.05）。除了一名患有III级软骨病变的患者外，滑膜组织中没有CD30阳性病例。结论：我们的结果表明，患有外桥IV级软骨损伤的患者的CD30 +淋巴细胞计数高于其他组，这与年龄相关。 CD30 +淋巴细胞的起源本身可能不是滑膜组织。因此，假设受伤的软骨组织和相关的软骨下结构可能是CD30 +淋巴细胞的来源，可能对骨关节炎的发展有影响。

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