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首页> 外文期刊>Current therapeutic research, clinical and experimental. >In Vitro Immunogenic and Immunostimulatory Effects of Zwitterionized 23-Valent Pneumococcal Polysaccharide Vaccine Compared With Nonzwitterionized Vaccine
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In Vitro Immunogenic and Immunostimulatory Effects of Zwitterionized 23-Valent Pneumococcal Polysaccharide Vaccine Compared With Nonzwitterionized Vaccine

机译：两性离子化的23价肺炎球菌多糖疫苗与非两性离子化疫苗的体外免疫原性和免疫刺激作用

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BACKGROUND: It was hypothesized that the observed slight immunostimulatory effect of the 23-valent pneumococcal polysaccharide (pneumo-23) vaccine might be due to the presence of low levels of zwitterionic motifs. Therefore, it was hypothesized further that introducing zwitterionic motifs experimentally into polysaccharides of pneumo-23 vaccine might render it an effective immunostimulatory agent.OBJECTIVE: This study was conducted to assess the in vitro immunostimulatory effect of zwitterionized pneumo-23 (Z-P23) vaccine compared with the nonzwitterionized commercial pneumo-23 (C-P23) vaccine.
机译：背景：假设观察到的23价肺炎球菌多糖（pneumo-23）疫苗的轻微免疫刺激作用可能是由于两性离子基序水平较低。因此，进一步假设将实验性的两性离子基序引入pneumo-23疫苗的多糖中可能使其成为一种有效的免疫刺激剂。目的：本研究旨在评估两性离子化的pneumo-23（Z-P23）疫苗的体外免疫刺激作用。与非两性离子化的商用pneumo-23（C-P23）疫苗相比。

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