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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Comparison of Ramosetron, Dexamethasone, and a Combination of Ramosetron and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting in Korean Women Undergoing Thyroidectomy: A Double-Blind, Randomized, Controlled Study
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Comparison of Ramosetron, Dexamethasone, and a Combination of Ramosetron and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting in Korean Women Undergoing Thyroidectomy: A Double-Blind, Randomized, Controlled Study

机译：雷莫司琼，地塞米松以及雷莫司琼和地塞米松联合在甲状腺切除术中预防韩国妇女术后恶心和呕吐的比较：一项双盲，随机对照研究

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BACKGROUND: Thyroidectomy is associated with a relatively high incidence of postoperative nausea and vomiting (PONV), ranging from 51% to 76%. Because these symptoms are distressing for patients, prophylactic medication to avoid or reduce PONV is recommended.OBJECTIVE: The aim of the present study was to compare the efficacy of ramosetron, dexamethasone, and a combination of ramosetron and dexamethasone in preventing PONV in Korean women undergoing thyroidectomy.METHODS: In this double-blind, randomized, controlled trial, consecutive adult female patients who were scheduled to undergo thyroidectomy under general anesthesia at the Kyungpook National University Hospital (Daegu, Korea) were randomly assigned to receive ramosetron 0.3 mg alone, dexamethasone 8 mg alone, or a combination of ramosetron 0.3 mg and dexamethasone 8 mg administered intravenously as a single dose immediately after induction of anesthesia. The primary end point of this study was the total PONV rate up to 24 hours postanesthesia. The secondary end points were the incidence of nausea, incidence of vomiting, severity of nausea (0 = no nausea to 10 = nausea as bad as it could be), use of rescue antiemetic drugs, and the occurrence of adverse events (AEs) determined through interview or spontaneous patient report for 24 hours postanesthesia.
机译：背景：甲状腺切除术与术后恶心和呕吐（PONV）的发生率相对较高有关，范围在51％至76％之间。由于这些症状令患者感到痛苦，因此建议使用预防药物来避免或减少PONV。目的：本研究的目的是比较雷莫司琼，地塞米松以及雷莫司琼和地塞米松的组合在韩国女性接受PONV预防中的功效。方法：在这项双盲，随机，对照试验中，计划在庆北国立大学医院（韩国大邱市）全麻行甲状腺切除术的连续成年女性患者随机分配接受雷莫司琼0.3 mg，地塞米松治疗。麻醉诱导后立即以单剂量静脉注射8 mg单独的雷莫司琼或0.3 mg雷莫司琼和地塞米松8 mg的组合。这项研究的主要终点是麻醉后24小时的总PONV率。次要终点是恶心的发生率，呕吐的发生率，恶心的严重程度（0 =无恶心至10 =恶心至极严重），使用抢救性止吐药以及确定不良事件（AE）的发生通过麻醉后24小时的访谈或自发的患者报告。

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