Tolerability and Effectiveness of (S)-Amlodipine Compared With Racemic Amlodipine in Hypertension: A Systematic Review and Meta-Analysis

Fang Liu; Meng Qiu; Suo Di Zhai

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Tolerability and Effectiveness of (S)-Amlodipine Compared With Racemic Amlodipine in Hypertension: A Systematic Review and Meta-Analysis

机译：（S）-氨氯地平与消旋氨氯地平在高血压中的耐受性和有效性：系统评价和荟萃分析

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BACKGROUND: Amlodipine is a calcium channel blocker prescribed for the management of angina and hypertension. As a racemic mixture, amlodipine contains (R)- and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity. Based on pharmacologic research, it remains uncertain if (S)-amlodipine alone has similar efficacy and fewer associated adverse events (AEs) compared with the racemic mixtures.OBJECTIVE: The aim of this systematic review and meta-analysis was to determine the effectiveness and tolerability of (S)-amlodipine compared with that of racemic amlodipine.

机译：背景：氨氯地平是一种用于治疗心绞痛和高血压的钙通道阻滞剂。作为消旋混合物，氨氯地平含有（R）-和（S）-氨氯地平异构体，但只有（S）-氨氯地平作为活性成分具有治疗活性。根据药理学研究，尚不确定与消旋混合物相比，仅（S）-氨氯地平是否具有相似的疗效和较少的相关不良事件（AE）。目的：进行系统评价和荟萃分析的目的是确定有效性和（S）-氨氯地平与消旋氨氯地平的耐受性。

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《Current therapeutic research, clinical and experimental.》 |2010年第1期|共29页
作者
Fang Liu; Meng Qiu; Suo Di Zhai;
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正文语种 eng
中图分类治疗学;
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1. Tolerability and Effectiveness of (S)-Amlodipine Compared With Racemic Amlodipine in Hypertension: A Systematic Review and Meta-Analysis [J] . Fang Liu, Meng Qiu, Suo Di Zhai Current therapeutic research, clinical and experimental. . 2010,第1期

机译：（S）-氨氯地平与消旋氨氯地平在高血压中的耐受性和有效性：系统评价和荟萃分析
2. Evaluation of the Efficacy and Tolerability of Combination Therapy With Candesartan Cilexetil and Amlodipine Besilate Compared With Candesartan Cilexetil Monotherapy and Amlodipine Besilate Monotherapy in Japanese Patients With Mild-to-Moderate Essential Hypertension: A Multicenter, 12-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study [J] . RakugiH., OgiharaT., MiyataY., Clinical therapeutics . 2012,第4期

机译：日本轻度至中度原发性高血压患者与Candesartan Cilexetil和苯磺酸氨氯地平联合疗法与Candesartan Cilexetil单一疗法和Amlodipine苯磺酸盐联合疗法的疗效和耐受性评估：多中心，12周，随机，双盲，安慰剂控制的平行小组研究
3. A Systematic Review on the Efficacy of Amlodipine in the Treatment of Patients With Hypertension With Concomitant Diabetes Mellitus and/or Renal Dysfunction, When Compared With Other Classes of Antihypertensive Medication [J] . Jeffers Barrett W., Robbins Jeffery, Bhambri Rahul, American journal of therapeutics . 2015,第5期

机译：与其他类别的降压药物相比，氨氯地平治疗合并糖尿病和/或肾功能不全的高血压患者的疗效的系统评价
4. Dynamic non-linear changes in heart rate variability in patients with coronary heart disease and arterial hypertension treated by amlodipine besylate [C] . Krstacic, G., Krstacic, . 2003

机译：苯磺酸氨氯地平治疗冠心病和动脉高血压患者心率变异性的动态非线性变化
5. Effects of Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Meta-analysis [D] . Behnamfar, Omid . 2020

机译：球囊肺血管成形术对慢性血栓栓塞肺动脉高压的影响：系统评价与荟萃分析
6. Tolerability and effectiveness of (S)-amlodipine compared with racemic amlodipine in hypertension: A systematic review and meta-analysis [O] . Fang Liu, Meng Qiu, Suo-Di Zhai 2010

机译：（S）-氨氯地平与消旋氨氯地平相比对高血压的耐受性和有效性：系统评价和荟萃分析
7. Tolerability and effectiveness of (S)-amlodipine compared with racemic amlodipine in hypertension: A systematic review and meta-analysis [O] . Liu Fang, Qiu Meng, Zhai Suo-Di 2010

机译：（S）-氨氯地平与消旋氨氯地平相比对高血压的耐受性和有效性：系统评价和荟萃分析

Tolerability and Effectiveness of (S)-Amlodipine Compared With Racemic Amlodipine in Hypertension: A Systematic Review and Meta-Analysis

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