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首页> 外文期刊>Aging cell. >Aging of the innate immune response in Drosophila melanogaster.
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Aging of the innate immune response in Drosophila melanogaster.

机译：果蝇的先天免疫反应的老化。

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Summary Increased activation of the innate immune system is a common feature of aging animals, including mammals and Drosophila melanogaster. With age, D. melanogaster progressively express higher levels of many antimicrobial peptides. It is unknown, however, whether this pattern reflects age-dependent changes in the function of the immune system itself or arises simply because aged adults have greater cumulative exposure to pathogens. Here we demonstrate that aged D. melanogaster transcribe more antimicrobial diptericin when experimentally exposed to septic bacterial infections. This strong net response in older females is the result of persistent diptericin transcription upon septic exposure, whereas young females rapidly terminate this induction. In contrast to their response to septic exposure, when exposed to killed bacteria aged females have less capacity to induce diptericin. Because this functional capacity of innate immunity declines with age, we conclude that female Drosophila undergo immune senescence. Furthermore, we show that fecundity is reduced by induction of innate immunity via the immune deficiency pathway. Consequently, maximum reproduction will occur when the immune response is tightly controlled in young females, even if this increases infection risk at later ages.
机译：小结固有免疫系统的激活增强是衰老动物（包括哺乳动物和果蝇果蝇）的共同特征。随着年龄的增长，黑腹果蝇逐渐表达更高水平的许多抗菌肽。但是，这种模式是否反映了免疫系统自身功能的年龄依赖性变化，还是仅仅由于老年人对病原体的累积暴露量较大而引起的，还是未知的。在这里，我们证明了当实验暴露于败血性细菌感染时，老年D. melanogaster转录出更多的抗微生物二萜。老年女性的这种强烈的净反应是败血症暴露后持久性双蝶呤转录的结果，而年轻女性则迅速终止这种诱导。与它们对败血症暴露的反应相反，当老年女性暴露于杀死的细菌时，其诱导二蝶呤的能力较小。由于先天免疫的这种功能能力随着年龄的增长而下降，因此我们得出结论，果蝇雌性会发生免疫衰老。此外，我们表明，通过免疫缺陷途径诱导的先天免疫力降低了繁殖力。因此，当严格控制年轻女性的免疫反应时，即使在以后的年龄增加感染风险，也将实现最大的繁殖。

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