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首页> 外文期刊>Current topics in membranes >The Role of Gap Junction Channels in theCiliary Body Secretory Epithelium
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The Role of Gap Junction Channels in theCiliary Body Secretory Epithelium

机译：间隙连接通道在睫状体分泌上皮中的作用。

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The secretory epithelium of the ciliary body is responsible for generatingthe aqueous humor (AH). The epithelium comprises two cell layers: the pigmented epithelium (PE) and non pigmented epithelium (NPE), whose apical surfaces appose one another. At the apical—apical interface, the twolayers are in communication through gap junctions formed from connexinsCx40 and Cx43. Cells of the PE are not in direct gap junctional communica-tion with each other; however, the cells of the NPE are coupled by gapjunctions made from Cx26 and Cx32. We first review the properties of theciliary body, then those of gap junction channels in general, with specialemphasis on channels made from the connexins present in the ciliary epithe-lium. An important question arises concerning the gap junction channels atthe apical—apical interface: Do these channels conduct the water that isultimately secreted? Model calculations are presented that suggest the chan-nels could do so, but only if they provide a rather high degree of ion coupling.Finally, experimental animal models, which might help test this hypothesis,are reviewed.
机译：睫状体的分泌上皮负责产生房水（AH）。上皮包括两个细胞层：有色上皮（PE）和无色上皮（NPE），其顶表面相互贴合。在顶-顶界面处，两层通过连接蛋白Cx40和Cx43形成的间隙连接而连通。 PE细胞之间没有直接的间隙连接通讯。但是，NPE的单元通过由Cx26和Cx32制成的间隙连接而耦合。我们首先回顾睫状体的特性，然后一般回顾间隙连接通道的特性，特别强调由睫状上皮中存在的连接蛋白制成的通道。关于顶-顶界面的间隙连接通道，出现了一个重要的问题：这些通道是否传导了最终分泌的水？提出的模型计算表明该通道可以这样做，但前提是它们提供了相当高的离子耦合程度。最后，对可能有助于检验该假设的实验动物模型进行了综述。

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