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首页> 外文期刊>Neuron >ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation.
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ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation.

机译：通过间隙连接半通道从色素上皮释放的ATP调节神经视网膜祖细胞的增殖。

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摘要

The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate DNA synthesis in neural retinal progenitor cells. Here, we show that the RPE regulates proliferation in the underlying neural retina by the release of a soluble factor and identify that factor as ATP. Further, we show that this ATP is released by efflux through gap junction connexin 43 hemichannels, the opening of which is evoked by spontaneous elevations of Ca2+ in trigger cells in the RPE. This release mechanism is localized within the RPE cells to the membranes facing the neural retina, a location ideally positioned to influence neural retinal development. ATP released from RPE hemichannels speeds both cell division and proliferation in the neural retina.
机译：视网膜色素上皮（RPE）在下面的神经视网膜的正常发育中起着至关重要的作用，但是这种调节发生的机制尚不清楚。由作用于嘌呤能受体的神经递质ATP诱导的Ca2 +瞬变既增加增殖又刺激神经视网膜祖细胞中DNA的合成。在这里，我们显示RPE通过释放可溶性因子来调节潜在的神经视网膜中的增殖，并将该因子识别为ATP。此外，我们显示该ATP是通过间隙连接连接蛋白43个半通道通过外排释放的，RPE触发细胞中Ca2 +的自发升高引起了它的开放。这种释放机制位于RPE细胞内，面向神经视网膜的膜，理想的位置是影响神经视网膜发育的位置。从RPE半通道释放的ATP加快了神经视网膜的细胞分裂和增殖。

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