Multicomponent Solvent-Free Synthesis Of Benzimidazolyl lmidazon,2-a]-pyridine Under Microwave Irradiation

Barnali Maiti; Kaushik Chanda; Manikandan Selvaraju

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Multicomponent Solvent-Free Synthesis Of Benzimidazolyl lmidazon,2-a]-pyridine Under Microwave Irradiation

机译：微波辐射下多组分无溶剂合成苯并咪唑基lmidazon，2-a]-吡啶

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A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodology facilitates the rapid generation of intricate molecular frameworks in three-dimensional fashion leading to benzimidazole-imidazo[1,2-a] pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biological interesting compounds. The present synthetic sequence permits the introduction of three points of structural diversity to expand chemical space with high purity and excellent yields.

机译：利用三氟甲磺酸scan（III）在无溶剂条件下，完成了一种新颖的一锅三组分反应，该反应采用了各种取代的苯并咪唑连接的氨基吡啶，醛和异腈。这种新的合成方法有助于以三维方式快速生成复杂的分子框架，从而生成苯并咪唑-咪唑并[1,2-a]吡啶。该方法被认为是对环境有益的过程，并且是对生物感兴趣的化合物的简单操作。本合成顺序允许引入结构多样性的三个点，以高纯度和优异的收率扩大化学空间。

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来源
《ACS combinatorial science》 |2013年第6期|共7页
作者
Barnali Maiti; Kaushik Chanda; Manikandan Selvaraju;
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正文语种 eng
中图分类化学;
关键词
microwave irradiation; benzimidazok-imidazo1; 2~apyridine$; solvent-free; bis-heterocyclic skeletons; three-component reaction;

机译：微波辐射;苯并咪唑咪唑并[1;2〜a]吡啶$;无溶剂;双杂环骨架;三组分反应;

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1. Multicomponent Solvent-Free Synthesis Of Benzimidazolyl lmidazon,2-a]-pyridine Under Microwave Irradiation [J] . Barnali Maiti, Kaushik Chanda, Manikandan Selvaraju ACS combinatorial science . 2013,第6期

机译：微波辐射下多组分无溶剂合成苯并咪唑基lmidazon，2-a]-吡啶
2. Microwave-accelerated three-component condensation reaction on clay: solvent-free synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines [J] . Varma RS., Kumar D. Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1999,第43期

机译：微波促进粘土上的三组分缩合反应：咪唑并[1,2-a]环吡啶，吡嗪和嘧啶的无溶剂合成
3. Microwave-assisted Synthesis of a 3-Aminoimidazo[l,2-a]-pyridine/ pyrazine Library by Fluorous Multicomponent Reactions and Subsequent Cross-coupling Reactions [J] . Yimin Lu, Wei Zhang QSAR & combinatorial science . 2004,第10期

机译：微波多组分荧光反应和随后的交叉偶联反应微波合成3-氨基咪唑并[1,2-a]-吡啶/吡嗪文库
4. Multistep Microwave-Assisted Solvent-Free Organic Reactions: Synthesis of 1,6-Disubstituted-4-Oxo-1,4-Dihydro-Pyridine-3-Carboxylic Acid Benzyl Esters [C] . Mauro Panunzio, Maria Antonietta Lentini, Eileen Campana, International Conference on Microwave and High Frequency Heating . 2006

机译：多步微波辅助溶剂有机反应：1,6-二取代-4-氧代-1,4-二氢 - 吡啶-3-羧酸苄基酯的合成
5. Synthesis of highly substituted 6-sulfanyl pyridines through multicomponent reactions [D] . Alruwaili, Nwal. 2018

机译：通过多组分反应合成高度取代的6-磺酰基吡啶
6. Potassium Hydroxide Impregnated Alumina (KOH-Alumina) as a Recyclable Catalyst for the Solvent-Free Multicomponent Synthesis of Highly Functionalized Substituted Pyridazines and/or Substituted Pyridazin-3(2H)-ones under Microwave Irradiation [O] . Hormi Mecadon, Bekington Myrboh 2011

机译：微波辐射下氢氧化钾浸渍的氧化铝（KOH-氧化铝）作为无溶剂多组分合成高功能取代的哒嗪和/或取代的哒嗪-3（2H）-的可回收催化剂
7. A novel method for the synthesis of 6-bromo-2-(3,4-dichlorophenyl)imidazo[1,2-a]pyridine using microwave irradiation [O] . Rajesh Bhavanishankar, Yadav D. Bodke, Venkatesh K. Bhovi, 2009

机译：微波辐射合成6-溴-2-（3,4-二氯苯基）咪唑并[1,2-a]吡啶的新方法

Multicomponent Solvent-Free Synthesis Of Benzimidazolyl lmidazon,2-a]-pyridine Under Microwave Irradiation

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