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首页> 外文期刊>ACS Macro Letters >Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure
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Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure

机译：具有固有抗菌特性的基于多肽的大孔冰晶石：大孔结构的重要性

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摘要

Synthetic polypeptide-based macroporous cryogels with inherent antimicrobial properties were prepared for potential water purification applications. Gels were chemically cross-linked through the amine residue of a polycationic polylysine-b-polyvaline block copolymer with glutaraldehyde as cross-linker under cryogenic conditions. These cryogels exhibited excellent water swelling and highly compressible mechanical properties owing to their macroporous structure. The antibacterial performance was evaluated based on E. coli viability, with cryogels exhibiting up to 95.6% reduction in viable E. coli after a brief 1 h incubation. In comparison to the hydrogel control, the presence of macropores is shown to be vital to the antimicrobial effect of the gels. The confined environment and increased antimicrobial surface area of the macropores is believed to result in a "trap and kill" mechanism. Mechanical strength and pore integrity of cryogels were also found to be determinants for antibacterial activity. Along with the lack of toxic leaching, these cryogels with inherent antimicrobial properties pose as potential candidates for use in biological and environmentally friendly water purification applications.
机译：具有潜在的抗微生物特性的基于多肽的合成大孔冷冻凝胶制备用于潜在的水净化应用。凝胶在低温条件下通过戊二醛作为交联剂，通过聚阳离子聚赖氨酸-b-聚缬氨酸嵌段共聚物的胺残基进行化学交联。这些冰凝胶由于其大孔结构而表现出优异的水溶胀性和高度可压缩的机械性能。根据大肠杆菌的生存能力评估其抗菌性能，经过短暂的1 h孵育​​后，冷冻凝胶在大肠杆菌中的存活率最多降低了95.6％。与水凝胶对照相比，大孔的存在对凝胶的抗菌作用至关重要。大孔的封闭环境和增加的抗菌表面积被认为导致“捕获并杀死”机制。还发现了冷冻凝胶的机械强度和孔完整性是抗菌活性的决定因素。随着缺乏有毒的浸出，这些具有固有抗微生物特性的冰凝胶成为生物和环保净水应用中潜在的候选物质。

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