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首页> 外文期刊>Current topics in medicinal chemistry >New treatment options using 5-HT3 receptor antagonists in rheumatic diseases.
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New treatment options using 5-HT3 receptor antagonists in rheumatic diseases.

机译：在风湿性疾病中使用5-HT3受体拮抗剂的新治疗选择。

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In vitro studies have shown that a blockade of 5-HT3 receptors brings about a reduction of tumor necrosis factor, IL-1 beta, IL-2, IL-6 as well as a decrease in prostaglandins. Clinical trials have provided evidence of pain reduction in a subgroup of fibromyalgia syndrome and, moreover, have demonstrated that tropisetron injected locally for insertion tendinoses and myofascial syndromes with associated trigger points leads to an alleviation of pain that is comparable to injections with the combination of corticosteroids and local anesthetics. The effects achieved by intra-articular injections in cases of osteoarthritis and rheumatoid arthritis paralleled those exerted by intraarticular injection of corticosteroids. In addition, the positive effects produced by systemically administered tropisetron on scleroderma need to be considered since they suggest that this therapeutic principle can also be applied systemically in immunologic processes.
机译：体外研究表明，对5-HT3受体的阻断导致肿瘤坏死因子IL-1β，IL-2，IL-6的减少以及前列腺素的减少。临床试验提供了纤维肌痛综合征亚组疼痛减轻的证据，此外，还证明了局部用肌力康注射用于插入肌腱炎和肌筋膜综合征并伴有相关触发点可减轻疼痛，其效果与注射皮质类固醇激素相当和局部麻醉剂。在骨关节炎和类风湿关节炎的情况下，通过关节腔内注射获得的效果与通过皮质类固醇的关节腔内注射所产生的效果相似。另外，需要考虑全身性使用原托克司琼对硬皮病产生的积极作用，因为它们表明该治疗原理也可以全身应用在免疫学过程中。

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