P-gp transporter and its role in neurodegenerative diseases.

Rapposelli S; Digiacomo M; Balsamo A

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P-gp transporter and its role in neurodegenerative diseases.

机译：P-gp转运蛋白及其在神经退行性疾病中的作用。

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This paper describes an overview of recent insights concerning some socially relevant neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) and Creutzfeldt-Jakob's (CJD) diseases, amyotrophic lateral sclerosis (ALS) and epilepsy. For each pathological state, the direct and/or indirect involvement of P-glycoprotein (P-gp) efflux transport is underlined. On this basis, P-gp still represents an innovative target which can offer new tools for the development of more effective and preventive therapeutic strategies for neurodegenerative disorders. For each of them, therefore, a possible use of drugs affecting P-gp transport activity has been suggested.

机译：本文介绍了有关一些与社会相关的神经退行性疾病的最新见解的概述，例如阿尔茨海默氏病（AD），帕金森氏病（PD），亨廷顿病（HD）和克雅氏病（CJD），肌萎缩性侧索硬化症（ALS）和癫痫病。对于每种病理状态，强调了P-糖蛋白（P-gp）外排转运的直接和/或间接参与。在此基础上，P-gp仍然是一个创新目标，可以为开发神经退行性疾病的更有效和预防性治疗策略提供新工具。因此，对于它们中的每一个，已经建议可能使用影响P-gp转运活性的药物。

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来源
《Current topics in medicinal chemistry》 |2009年第2期|共9页
作者
Rapposelli S; Digiacomo M; Balsamo A;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
P-Glycoprotein; Membrane Transport Proteins; Role; Amyotrophic Lateral Sclerosis; P-糖蛋白; 角色; 肌萎缩侧索硬化;

机译：P-Glycoprotein;Membrane Transport Proteins;Role;Amyotrophic Lateral Sclerosis;P-糖蛋白;角色;肌萎缩侧索硬化;

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1. P-gp transporter and its role in neurodegenerative diseases. [J] . Rapposelli S, Digiacomo M, Balsamo A Current topics in medicinal chemistry . 2009,第2期

机译：P-gp转运蛋白及其在神经退行性疾病中的作用。
2. Targeting CNS transporters for treatment of neurodegenerative diseases. [J] . Gabriele Jedlitschky, Markus Grube, Igor Mosyagin, Current pharmaceutical design . 2014,第10期

机译：靶向中枢神经系统转运蛋白治疗神经退行性疾病。
3. Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases. [J] . Campiani G, Fattorusso C, De Angelis M, Current pharmaceutical design . 2003,第8期

机译：神经元高亲和力钠依赖性谷氨酸转运蛋白（EAATs）：开发针对神经退行性疾病的新型疗法的目标。
4. Nanoimaging for Protein Misfolding Diseases. Critical Role of Misfolded Dimers in the Amyloid Self-Assembly [C] . Alexey V. Krasnoslobodtsev, Bo-Hyun Kim, Yuri L. Lyubchenko International Metallographic Society Annual meeting;Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting . 2011

机译：用于蛋白质错误折叠疾病的纳米成像。错误折叠的二聚体在淀粉样蛋白自组装中的关键作用。
5. Physiological roles of disease-associated proteins in neurodegenerative diseases. [D] . Chiang, Po-Min. 2010

机译：疾病相关蛋白在神经退行性疾病中的生理作用。
6. Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp) Breast Cancer Resistance Protein (Bcrp) and P-gp/Bcrp Knockout Mice [O] . Sagar Agarwal, Yasuo Uchida, Rajendar K. Mittapalli, -1

机译：从P-糖蛋白（P-gp）乳腺癌抗性蛋白（Bcrp）和P-gp / Bcrp敲除小鼠分离的脑毛细血管内皮细胞中转运蛋白表达的定量蛋白质组学
7. The IC50 for Inhibition of Digoxin Transport Across Confluent Cell Monolayers of P-gp Expressing Cell Lines is Often a Function of Inhibitor Binding to Both P-gp and an Unidentified Basolateral Digoxin Uptake Transporter [O] . Bentz Joe 2013

机译：抑制地高辛跨表达P-gp的细胞系的融合细胞单层转运的IC50通常是抑制剂与P-gp和未知的基底外侧地高辛摄取转运蛋白结合的功能。

P-gp transporter and its role in neurodegenerative diseases.

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