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Methodological Issues and Possible Clinical Implications for Exhaled Breath Condensate pH in Asthma

机译:哮喘呼出气冷凝物pH值的方法学问题和可能的临床意义

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摘要

Exhaled breath condensate (EBC) pH is a commonly studied biomarker which represents the acidity of the whole airway tract, including the lower and upper airways as well as oral cavity. Because neat, unprocessed EBC pH can be affected by environmental and end-tidal carbon dioxide, two further reproducible techniques have been developed to measure condensate acidity with several methodological, pathophysiological and environmental factors which may influence EBC pH. Airway acidification may contribute to various pathological features of asthma, therefore EBC pH may be a non-invasive, but unspecific clinical biomarker of this disorder. This review summarises the current knowledge on EBC pH in asthma focusing on methodological aspects and possible clinical applications.
机译:呼出气冷凝物(EBC)的pH值是一项经过广泛研究的生物标志物,它代表整个气道的酸度,包括上下呼吸道以及口腔。由于纯净的,未经处理的EBC pH会受到环境和潮气中二氧化碳的影响,因此开发了另外两种可重现的技术来测量冷凝物酸度,其中包括几种可能影响EBC pH的方法,病理生理和环境因素。气道酸化可能导致哮喘的各种病理特征,因此EBC pH可能是该疾病的一种非侵入性但非特异性的临床生物标记。这篇综述总结了关于哮喘中EBC pH的当前知识,重点是方法论方面和可能的临床应用。

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