One-Pot Multicomponent Synthesis of Highly Functionalized Piperidines from Substituted β-Nitrostyrenes, Meldrum's Acid, Aromatic Aldehydes, and Ammonium Acetate

Yan Li; Zhiheng Xue; Weijian Ye

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One-Pot Multicomponent Synthesis of Highly Functionalized Piperidines from Substituted β-Nitrostyrenes, Meldrum's Acid, Aromatic Aldehydes, and Ammonium Acetate

机译：由取代的β-硝基苯乙烯，Meldrum酸，芳族醛和乙酸铵一锅多组分合成高功能性哌啶

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摘要

An efficient and straightforward synthetic protocol has been developed for the diversity-oriented synthesis of highly functionalized piperidines containing a Meldrum's acid moiety via pseudo five-component reaction between aromatic aldehydes, ammonium acetate, substituted β-nitrostyrenes and Meldrum's acid for the generation of a wide range of structurally interesting and pharmacologically significant compounds.

机译：通过芳香醛，乙酸铵，取代的β-硝基苯乙烯和Meldrum酸之间的假五组分反应，已开发出一种高效，直接的合成方案，用于多样性导向的合成具有Meldrum酸部分的高度官能化哌啶，从而产生了广泛的一系列结构上有意义且在药理上有意义的化合物。

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《ACS combinatorial science》 |2014年第3期|共7页
作者
Yan Li; Zhiheng Xue; Weijian Ye;
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正文语种 eng
中图分类化学;
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multicomponent reaction; polysubstituted piperidine; aromatic aldehyde; Meldrum's acid; substituted nitrostyrene;

机译：多组分反应多取代哌啶芳香醛马德拉姆酸取代硝基苯乙烯;

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1. One-Pot Multicomponent Synthesis of Highly Functionalized Piperidines from Substituted β-Nitrostyrenes, Meldrum's Acid, Aromatic Aldehydes, and Ammonium Acetate [J] . Yan Li, Zhiheng Xue, Weijian Ye ACS combinatorial science . 2014,第3期

机译：由取代的β-硝基苯乙烯，Meldrum酸，芳族醛和乙酸铵一锅多组分合成高功能性哌啶
2. Novel Synthesis of Substituted Furo[3,2-c]chromen-4-ones via Four-component Reaction from Substituted Nitrostyrenes, Aromatic Aldehydes, Coumarins, and Ammonium Acetate [J] . Zhengquan Zhou, Hui Liu, Yun Li ACS combinatorial science . 2013,第7期

机译：通过四组分反应由取代的硝基苯乙烯，芳族醛，香豆素和乙酸铵合成四价取代的呋喃[3,2-c] chromen-4-ones
3. One-pot synthesis of 2,4,6-triarylpyridines from beta-nitrostyrenes, substituted salicylic aldehydes and ammonium acetate [J] . Qing Xushun, Wang Ting, Zhang Feixiang, RSC Advances . 2016,第98期

机译：来自β-硝化丁烯的2,4,6-三芳基吡啶的单壶合成，取代的水杨酸醛和乙酸铵
4. Highly efficient, one-pot, solvent-free synthesis of highly substituted imidazoles using molecular iodine as catalyst [C] . Yi-Ming Ren, Chun Cai International Conference on Chemical, Material and Metallurgical Engineering . 2012

机译：使用分子碘作为催化剂高效，单罐，无溶剂合成高度取代的咪唑
5. Stereoselective functionalization of Meldrum's acids and the efforts toward total synthesis of echinosporin. [D] . Do, Dung Tien. 2014

机译：Meldrum酸的立体选择性官能化以及棘孢菌素的全合成努力。
6. Potassium Hydroxide Impregnated Alumina (KOH-Alumina) as a Recyclable Catalyst for the Solvent-Free Multicomponent Synthesis of Highly Functionalized Substituted Pyridazines and/or Substituted Pyridazin-3(2H)-ones under Microwave Irradiation [O] . Hormi Mecadon, Bekington Myrboh 2011

机译：微波辐射下氢氧化钾浸渍的氧化铝（KOH-氧化铝）作为无溶剂多组分合成高功能取代的哒嗪和/或取代的哒嗪-3（2H）-的可回收催化剂
7. A novel route for the diastereoselective synthesis of dispirotetrahydroquinoline-bis(2,2-dimethyl1,3dioxane-4,6-dione) derivatives via a one-pot domino multicomponent reaction of arylamines, aromatic aldehydes, and meldrum's acid [O] . Lashkari Mojtaba, Maghsoodlou Malek Taher, Hazeri Nourallah, 2016

机译：通过芳胺，芳族醛和me的一锅多米诺骨牌多组分反应，非对映选择性合成二螺四氢喹啉-双（2,2-二甲基1,3二恶烷-4,6-二酮）衍生物的非对映选择性的新途径酸

One-Pot Multicomponent Synthesis of Highly Functionalized Piperidines from Substituted β-Nitrostyrenes, Meldrum's Acid, Aromatic Aldehydes, and Ammonium Acetate

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