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High-intensity interval training increases the rate of mitochondrial fatty acid oxidation in rat skeletal muscle

机译:高强度的 间隔 训练增加 线粒体 脂肪酸氧化 的 大鼠 骨骼肌 率

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Purpose: High-intensity interval training (HIIT) can increase mitochondrial volume and density and induce an increase in oxidative capacity in skeletal muscle. HIIT also increases substrate transport protein associated with carbohydrate such as glucose and lactate. However, it is unclear whether HIIT alters the intrinsic capacity of mitochondria to oxidize substrates and fatty acid transport protein in skeletal muscle. It is known that there are subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria in skeletal muscle. We hypothesized that HIIT would increase rates of fatty acid and pyruvate oxidation in IMF mitochondria, because IMF mitochondria distribute between the myofibrils and we predicted that exercise training would stimulate IMF mitochondria to a greater extent. To clarify this hypothesis, we examined effects of HIIT on contents of mitochondrial substrate transporter protein, mitochondrial enzyme activities and substrates oxidation rates in isolated SS and IMF mitochondria in skeletal muscle.
机译:目的:高强度间隔训练(HIIT)可以提高线粒体体积和密度,并诱导骨骼肌中氧化能力的增加。 HIIT还增加与葡萄糖和乳酸的碳水化合物相关的基质传输蛋白。然而,目前尚不清楚HEIT是否改变了线粒体的内在能力,以在骨骼肌中氧化底物和脂肪酸输送蛋白。众所周知,在骨骼肌中存在子系统肠道(SS)和INTMYOFIBRILLAR(IMF)线粒体。我们假设HIIT将增加脂肪酸和丙酮酸氧化率在IMF线粒体中,因为IMF线粒体在肌原纤维之间分布,我们预测运动培训将在更大程度上刺激IMF线粒体。为了阐明这一假设,我们研究了HIIT对线粒体底物转运蛋白,线粒体酶活性和基质氧化率的HIIT在骨骼肌中分离的SS和IMF线粒体中的氧化率的影响。

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