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首页> 外文期刊>American Journal of Veterinary Research >Effect of infection with bovine respiratory syncytial virus on pulmonary clearance of an inhaled antigen in calves.
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Effect of infection with bovine respiratory syncytial virus on pulmonary clearance of an inhaled antigen in calves.

机译：牛呼吸道合胞病毒感染对犊牛吸入抗原的肺部清除的影响。

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OBJECTIVE: To evaluate the effect of infection with bovine respiratory syncytial virus (BRSV) on clearance of inhaled antigens from the lungs of calves. ANIMALS: Eleven 6- to 8-week-old Holstein bull calves. PROCEDURES: Aerosolized (99m)technetium ((99m)Tc)-labeled diethylene triamine pentacetate (DTPA; 3 calves), commonly used to measure integrity of the pulmonary epithelium, and (99m)Tc-labeled ovalbumin (OA; 8 calves), commonly used as a prototype allergen, were used to evaluate pulmonary clearance before, during, and after experimentally induced infection with BRSV or sham inoculation with BRSV. Uptake in plasma (6 calves) and lung-efferent lymph (1 calf) was examined. RESULTS: Clearance of (99m)Tc-DTPA was significantly increased during BRSV infection; clearance of (99m)Tc-OA was decreased on day 7 after inoculation. Clearance time was correlated with severity of clinical disease, and amounts of (99m)Tc-OA in plasma and lymph were inversely correlated with clearance time. Minimum amounts of (99m)Tc-OA were detected at time points when pulmonary clearance of (99m)Tc-OA was most delayed. CONCLUSIONS AND CLINICAL RELEVANCE: BRSV caused infection of the respiratory tract with peak signs of clinical disease at 7 or 8 days after inoculation. Concurrently, there was a diminished ability to move inhaled protein antigen out of the lungs. Prolonged exposure to inhaled antigens during BRSV infection may enhance antigen presentation with consequent allergic sensitization and development of chronic inflammatory lung disease. IMPACT FOR HUMAN MEDICINE: Infection of humans with respiratory syncytial virus early after birth is associated with subsequent development of allergic asthma. Results for BRSV infection in these calves suggested a supportive mechanism for this scenario.
机译：目的：评估牛呼吸道合胞病毒（BRSV）感染对犊牛肺部吸入抗原清除的影响。动物：11头6至8周大的荷斯坦公牛犊。程序：雾化的（99m）（（（99m）Tc）标记的二亚乙基三胺五乙酸二乙酯（DTPA; 3头犊牛），通常用于测量肺上皮的完整性，和（99m）Tc标记的卵白蛋白（OA; 8头犊牛），通常用作原型过敏原的样品，用于在实验诱导的BRSV感染或BRSV假接种之前，期间和之后评估肺部清除率。检查血浆（6条小腿）和肺有效淋巴（1条小腿）的摄取。结果：BRSV感染期间（99m）Tc-DTPA的清除率显着增加。接种后第7天（99m）Tc-OA的清除率降低。清除时间与临床疾病的严重程度相关，血浆和淋巴中（99m）Tc-OA的量与清除时间成反比。在（99m）Tc-OA的肺部清除最延迟的时间点检测到最小量的（99m）Tc-OA。结论和临床意义：BRSV在接种后7或8天引起呼吸道感染，临床疾病达到高峰。同时，将吸入的蛋白抗原移出肺部的能力减弱。在BRSV感染期间长时间暴露于吸入抗原可能会增强抗原呈递，从而导致过敏性致敏和慢性炎症性肺病的发展。对人类医学的影响：出生后早期感染呼吸道合胞病毒的人与过敏性哮喘的继发发展有关。这些小牛的BRSV感染结果提示了这种情况的支持机制。

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