...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Veterinary Research >Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine, and exercise in horses.
【24h】

Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine, and exercise in horses.

机译：美洛昔康和苯基丁氮酮对马对速尿，多巴酚丁胺和运动的肾脏反应的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective - To compare the effects of 2 NSAIDs (phenylbutazone and meloxicam) on renal function in horses. Animals - 9 Thoroughbred or Standardbred mares (meanSD age, 5.221.09 years [range, 2 to 12 years]; mean body weight, 47025 kg [range, 442 to 510 kg]). Procedures - A randomized blinded placebo-controlled crossover study was conducted to examine the effects of treatment with phenylbutazone, meloxicam, or a placebo (control solution) on renal responses to the administration of furosemide, dobutamine, and exercise (15 minutes at 60% of maximum heart rate). Renal function was assessed by use of bilateral ureteral catheterization for simultaneous determination of creatinine clearance, sodium excretion, and urine flow rate. Results - Both phenylbutazone and meloxicam attenuated diuresis and natriuresis and reduced glomerular filtration rate, compared with results for the control solution, when horses were treated with furosemide. Mean arterial blood pressure, urine flow rate, and glomerular filtration rate were increased during or after (or both) dobutamine infusion. Both NSAIDs reduced urine flow rate and sodium excretion associated with dobutamine infusion and exercise but had no effect on glomerular filtration rate. Conclusions and Clinical Relevance-Responses to meloxicam, a cyclooxygenase (COX)-2 preferential agent, appeared comparable to those detected after phenylbutazone treatment, which suggested that COX-2 was the mediator of prostanoid-induced changes to renal function in horses and indicated that COX-2-preferential agents would be likely to have adverse renal effects similar to those for nonselective COX inhibitors in volume-depleted horses.
机译：目的-比较2种NSAID（苯基丁a和美洛昔康）对马肾功能的影响。动物-9匹纯种或纯种母马（平均年龄，5.221.09岁[范围：2至12岁];平均体重：47025 kg [范围：442至510 kg]）。程序-进行了一项随机双盲安慰剂对照交叉研究，以研究苯基丁with酮，美洛昔康或安慰剂（对照溶液）治疗对呋塞米，多巴酚丁胺和运动的肾脏反应的影响（以60％的剂量进行15分钟）最大心率）。通过双侧输尿管插管同时测定肌酐清除率，钠排泄量和尿流率来评估肾功能。结果-当使用速尿治疗马匹时，与对照溶液相比，苯丁氮酮和美洛昔康都减弱了利尿和利尿作用，降低了肾小球滤过率。多巴酚丁胺输注期间或之后（或两者），平均动脉血压，尿流率和肾小球滤过率均升高。两种NSAID均可降低多巴酚丁胺输注和运动引起的尿流率和钠排泄，但对肾小球滤过率没有影响。结论和临床相关性-对环氧合酶（COX）-2优先剂美洛昔康的反应似乎与苯基丁treatment治疗后检测到的反应相当，这表明COX-2是前列腺素介导的马肾功能变化的介质。在体积减少的马匹中，与非选择性COX抑制剂相似，COX-2优先剂可能具有不利的肾脏作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号