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首页> 外文期刊>American Journal of Ophthalmology: The International Journal of Ophthalmology >Prevalence and risk factors for age-related macular degeneration in Indians: A comparative study in Singapore and India
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Prevalence and risk factors for age-related macular degeneration in Indians: A comparative study in Singapore and India

机译：印度人年龄相关性黄斑变性的患病率和危险因素：新加坡和印度的比较研究

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Purpose: To compare the prevalence and risk factors for age-related macular degeneration (AMD) in 2 Indian populations, 1 living in urban Singapore and 1 in rural central India. Design: Population-based, cross-sectional studies of Indians aged 40+ years. Methods: Our analysis included 3337 Singapore-residing participants and 3422 India-residing participants. All participants underwent comprehensive systemic and ocular examinations and retinal photography. AMD was graded from retinal photographs according to the Wisconsin Age-Related Maculopathy Grading System. Systemic and ocular risk factors were assessed for association with AMD. Results: Singapore-residing participants were older (mean age 57.8 years vs 53.8 years) and, after adjusting for age and sex, were more likely to have previous cataract surgery, higher body mass index, hypertension, diabetes, previous myocardial infarction, higher cholesterol, and lower creatinine levels, but less likely to be current smokers, than India-residing participants. The age-standardized prevalence of early and late AMD was 4.45% and 0.34%, respectively, in Singapore and 5.80% and 0.16%, respectively, in India. Shorter axial length was associated with early AMD in both Singapore and India, whereas previous cataract surgery, higher body mass index, hypertension, and lower cholesterol were associated with early AMD in Singapore but not in India. Conclusion: The prevalence of AMD was similar among Indian adults living in urban Singapore and rural India, despite differences in cardiovascular risk factor profile and demographics.
机译：目的：比较2个印度人口中的年龄相关性黄斑变性（AMD）的患病率和危险因素，其中1个生活在新加坡城市，1个生活在印度中部农村。设计：基于人口的40岁以上印第安人横断面研究。方法：我们的分析包括3337名新加坡居民和3422名印度居民。所有参与者均接受了全面的全身和眼部检查以及视网膜摄影。根据威斯康星州年龄相关性黄斑病变分级系统，从视网膜照片中对AMD进行分级。评估全身和眼部危险因素是否与AMD相关。结果：居住在新加坡的参与者年龄较大（平均年龄57.8岁vs 53.8岁），并且在调整了年龄和性别后，他们更可能接受过白内障手术，更高的体重指数，高血压，糖尿病，先前的心肌梗塞，更高的胆固醇，并且肌酐水平较低，但比印度居民更容易吸烟。在新加坡，AMD早期和晚期的年龄标准化患病率分别为4.45％和0.34％，在印度分别为5.80％和0.16％。在新加坡和印度，轴距较短与早期AMD有关，而在新加坡，印度以前与白内障手术，较高的体重指数，高血压和较低的胆固醇与AMD早期有关。结论：尽管心血管危险因素特征和人口统计学存在差异，但居住在新加坡市区和印度农村的印度成年人中AMD的患病率相似。

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