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首页> 外文期刊>American Journal of Ophthalmology: The International Journal of Ophthalmology >Study of macular function by multifocal electroretinography in patients with Vogt-Koyanagi-Harada syndrome.
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Study of macular function by multifocal electroretinography in patients with Vogt-Koyanagi-Harada syndrome.

机译：Vogt-Koyanagi-Harada综合征患者的多焦点视网膜电图研究黄斑功能。

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Purpose: We longitudinally investigated macular function by multifocal electroretinography (mfERG) in a cohort of patients with Vogt-Koyanagi-Harada (VKH) syndrome. DESIGN: Prospective study. METHODS: VKH syndrome was diagnosed in 11 patients (22 eyes) according to history and ocular examinations. They were treated with immunosuppressive agents and the macular function was evaluated using best-corrected visual acuity (BCVA) and mfERG before treatment and one, three, six, and 12 months after treatment. RESULTS: All investigated patients with VKH syndrome showed active intraocular inflammation at their first visit. A decreased visual acuity (VA) and abnormalities of mfERG were observed in all these patients. VA rapidly improved at one and three months and gradually improved thereafter. All but one eye achieved a BCVA of > or =20/25 at 12 months following treatment. The N1 amplitude and latency were significantly improved at three and six months and continuously improved thereafter. The P1 amplitude and latency were significantly improved at one and three months and progressively improved thereafter. However, the amplitude of N1 and P1 waves was still significantly decreased at 12 months. CONCLUSION: Macular function revealed by Snellen chart and mfERG is severely impaired in VKH patients with active uveitis. Treatment with immunosuppressive agents leads to an earlier, faster, and better recovery of VA, and a delayed but limited recovery of macular function as indicated by mfERG at 12 months. MfERG could be an ancillary test that may be useful in guiding therapy of patients with VKH syndrome.
机译：目的：我们通过多焦点视网膜电图（mfERG）纵向研究了一组Vogt-Koyanagi-Harada（VKH）综合征患者的黄斑功能。设计：前瞻性研究。方法：根据病史和眼科检查，诊断出11例（22只眼）VKH综合征。他们接受了免疫抑制剂治疗，并在治疗前以及治疗后1、3、6和12个月使用最佳矫正视力（BCVA）和mfERG评估了黄斑功能。结果：所有接受调查的VKH综合征患者在初诊时均表现为活动性眼内炎症。在所有这些患者中均观察到视力下降（VA）和mfERG异常。视力在一个月和三个月迅速改善，此后逐渐改善。治疗后12个月，除一只眼睛外，所有眼睛的BCVA均≥20/25。在三个月和六个月时，N1振幅和潜伏期显着改善，此后持续改善。 P1振幅和潜伏期在一个月和三个月显着改善，此后逐渐改善。但是，N1和P1波的振幅在12个月时仍显着降低。结论：活动性葡萄膜炎VKH患者的Snellen图和mfERG显示黄斑功能严重受损。如mfERG在12个月时所表明的，用免疫抑制剂治疗可导致VA的更早，更快和更好的恢复，以及黄斑功能的延迟但有限的恢复。 MfERG可能是辅助测试，可能对指导VKH综合征患者的治疗有用。

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