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首页> 外文期刊>American Journal of Ophthalmology: The International Journal of Ophthalmology >Update on Antiviral Treatment of Adenoviral Ocular Infections
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Update on Antiviral Treatment of Adenoviral Ocular Infections

机译：腺病毒眼感染抗病毒治疗的最新进展。

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摘要

SINCE THE INITIAL DESCRIPTION OF EPIDEMIC ADENO-viral ocular infections in Austria in 18891 until the present day, no effective drug to treat such patients has been found. Today, acute adenoviral ocular infections (epidemic keratoconjunctivitis, follicular conjunctivitis, and pharyngeal conjunctival fever) remain among the most common external ocular viral infections seen clinically worldwide, with more than one million cases annually in Japan.2 There are 51 serotypes of adenovirus, of which approximately one-half have been shown to cause ocular disease.3 The American Academy of Ophthalmology Preferred Practice Pattern proposes symptomatic treatment for these infections and the use of topical steroids to reduce scarring in severe cases of adenoviral keratoconjunctivitis with marked chemosis or lid swelling, epithelial sloughing, or membranous conjunctivitis.4 Lacking an effective Food and Drug Administration-approved antiviral, clinicians recognize the continuing need to develop a drug to reduce patient morbidity, to reduce the extent of or entirely prevent the formation of vision-altering subepi-thelial infiltrates, to reduce lost time from school or work, and to reduce or prevent the transmission of ocular infections within households, communities, and medical facilities#
机译：自从18891年在奥地利开始流行性腺病毒-病毒性眼部感染的描述以来，一直没有发现有效的药物来治疗此类患者。如今，急性腺病毒性眼部感染（流行性角膜结膜炎，滤泡性结膜炎和咽部结膜热）仍然是全世界临床上最常见的外部眼部病毒感染，在日本每年超过一百万例。2腺病毒的血清型为51种其中约有一半被证明会引起眼部疾病。3美国眼科院首选手术模式建议对这些感染进行对症治疗，并使用局部类固醇来减少严重腺癌性角膜结膜炎伴明显的化学反应或眼睑肿胀的瘢痕形成， 4缺乏有效的食品和药物管理局批准的抗病毒药，临床医生认识到继续需要开发一种药物来降低患者的发病率，以减少或完全防止改变视力的上皮下膜形成渗透，以减少因学校或工作所浪费的时间rk，并减少或预防家庭，社区和医疗机构内眼部感染的传播＃

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