Variation in proton affinity of the guanidino group between free and blocked arginine

Y.Liu; L.Jin; J.-B.Hou

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Variation in proton affinity of the guanidino group between free and blocked arginine

机译：游离和封闭精氨酸之间胍基的质子亲和力变化

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In this paper,the analog of arginine residues in peptides was synthesized and characterized by ESI-MS/MS(electrospray ionization with tandem mass spectrometry),~(31)P NMR,~1H NMR,IR and high-resolution mass spectrometry.When the Todd reaction activity of the guanidino group in free arginine and the arginine peptide analog were compared,it was found that the proton affinity of the guanidino group was decreased when both the N-and the C-terminal were blocked.As a result,the guanidino group of arginine residues in peptides could be phosphorylated under the Todd reaction condition,but not the free arginine.This result was further proved by the theoretical calculation of their proton affinity.

机译：本文通过ESI-MS / MS（串联质谱电喷雾电离），〜（31）P NMR，〜1H NMR，IR和高分辨质谱对肽中精氨酸残基的类似物进行了合成和表征。比较了游离精氨酸和精氨酸肽类似物中胍基的托德反应活性，发现当N-和C-末端均被封闭时，胍基的质子亲和力降低。肽中的精氨酸残基的胍基在托德反应条件下可以被磷酸化，而游离精氨酸则不能被磷酸化。这一结果通过其质子亲和力的理论计算得到了进一步证明。

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《Amino acids》 |2007年第1期|共6页
作者
Y.Liu; L.Jin; J.-B.Hou;
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正文语种 eng
中图分类生物化学;
关键词
Arginine residues; Guanidino group; Proton affinity; Todd reaction;

机译：精氨酸残基;胍基基团;质子亲和力;托德反应;

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1. Variation in proton affinity of the guanidino group between free and blocked arginine [J] . Y.Liu, L.Jin, J.-B.Hou Amino acids . 2007,第1期

机译：游离和封闭精氨酸之间胍基的质子亲和力变化
2. Exceptional proton affinities of push-pull nitriles substituted by the guanidino and phosphazeno groups [J] . Raczynska Ewa D., Gal Jean-Francois, Maria Pierre-Charles RSC Advances . 2015,第32期

机译：被胍基和磷氮杂基取代的推挽腈具有非凡的质子亲和力
3. Induced fit in guanidino kinases-comparison of substrate-free and transition state analog structures of arginine kinase. [J] . Yousef MS, Clark SA, Pruett PK, Protein Science: A Publication of the Protein Society . 2003,第1期

机译：胍基激酶的诱导适应性-精氨酸激酶的无底物和过渡态类似物结构的比较。
4. Synthesis via ROMP of triazole bearing polycyclobutene diblock copolymers as water-free proton conducting membranes for PEM fuel cells [C] . Jia Wei, William Trout, Sergio Granados-Focil National Meeting Exhibition . 2013

机译：通过三唑轴承多环丁烯二嵌段共聚物的合成作为PEM燃料电池的无水质子导电膜
5. PROTON-PROTON QUASIFREE SCATTERING DEUTERON(PROTON,2 PROTON)NEUTRON REACTION AT 40 MEV. [D] . BEATTY, PHILIP HAROLD. 1972

机译：40 MEV时质子-质子四级散射氘（质子，2质子）中子反应。
6. Induced fit in guanidino kinases—comparison of substrate-free and transition state analog structures of arginine kinase [O] . Mohammad S. Yousef, Shawn A. Clark, Pamela K. Pruett, 2003

机译：诱导的鸟嘌呤激酶的拟合-精氨酸激酶的无底物和过渡态类似物结构的比较
7. Variation in proton affinity of the guanidino group between free and blocked arginine [O] . Liu Y., Jin L., Hou J.-B., 2007

机译：游离和封闭精氨酸之间胍基的质子亲和力变化
8. Ion Chemistry of Cyanides and Isocyanides. 1. The Carbon Lone Pair as Proton Acceptor: Proton Affinities of Isocyanides. Alkyl Cation Affinities of N, O, and C Lone-Pair Donors [R] . Mautner, M. M., Karpas, Z., Deakyne, C. A. 1986

机译：氰化物和异氰化物的离子化学。 1.碳孤对作为质子受体：异氰化物的质子亲和力。 N，O和C孤对子供体的烷基阳离子亲和力

Variation in proton affinity of the guanidino group between free and blocked arginine

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