...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Amino acids >Selenomethionine induces polyamine biosynthesis in regenerating rat liver tissue
【24h】

Selenomethionine induces polyamine biosynthesis in regenerating rat liver tissue

机译：硒代蛋氨酸在再生大鼠肝组织中诱导多胺生物合成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our study was undertaken to elucidate the effects of selenomethionine (SeMet) on polyamine metabolism in regenerating rat liver tissue,as useful model of rapidly growing normal tissue.We have examined the levels of spermine,spermidine and putrescine in liver tissue.At the same time we have evaluated the activities of polyamine oxidase (PAO) and diamine oxidase (DAO),the catabolic enzymes of polyamine metabolism.The obtained results suggest that polyamine levels in regenerating liver tissue,at 7~(th) day after two-thirds partial hepatectomy,were higher in comparison with control group.The administration of selenomethionine to hepatectomized animals during seven days,in a single daily dose of 2.5 mug/100g body weight,increases the amount of spermine and spermidine;the level of putrescine does not change under the influence of SeMet in regenerating rat liver tissue.PAO activity is lower in regenerating hepatic tissue than in control group.Supplementation of hepatectomized animals with SeMet signifi-candy decreases the activity of this enzyme.DAO activity was significantly higher in hepatectomized and in operated animals treated with SeMet compared to the sham-operated and control ones.The differential sensitivity observed in our model of highly proliferating normal tissue to SeMet,compared with the reported anticancer activity of this molecule is discussed.
机译：我们的研究旨在阐明硒代蛋氨酸（SeMet）对再生的大鼠肝脏组织中多胺代谢的影响，作为快速生长的正常组织的有用模型。我们检查了肝脏组织中精胺，亚精胺和腐胺的水平。我们评估了多胺代谢的分解代谢酶多胺氧化酶（PAO）和二胺氧化酶（DAO）的活性。获得的结果表明，在三分之二的部分肝切除术后第7天，再生肝组织中的多胺水平，在七天之内，每天2.5杯/ 100克体重的每日剂量给肝脏切除的动物施用硒代蛋氨酸，增加了精胺和亚精胺的含量;在该条件下腐胺的水平没有变化。 SeMet对再生大鼠肝组织的影响。再生肝组织中的PAO活性低于对照组.SeM对肝切除动物的补充等显着降低了这种酶的活性。与假手术和对照组相比，用SeMet处理的肝切除和手术动物中的DAO活性明显更高。在我们高度增殖的正常组织对SeMet的模型中观察到的差异敏感性，与已报道的该分子的抗癌活性进行了比较。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号