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首页> 外文期刊>American journal on intellectual and developmental disabilities: AJIDD >Physiological Arousal in Autism and Fragile X Syndrome: Group Comparisons and Links With Pragmatic Language
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Physiological Arousal in Autism and Fragile X Syndrome: Group Comparisons and Links With Pragmatic Language

机译：自闭症和脆弱X综合征的生理唤醒：群体比较和与实用语言的联系

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摘要

This study tested the hypothesis that pragmatic (i.e., social) language impairment is linked to arousal dysregulation in autism spectrum disorder (ASD) and fragile X syndrome (FXS). Forty boys with ASD, 39 with FXS, and 27 with typical development (TD), aged 4-15 years, participated. Boys with FXS were hyperaroused compared to boys with TD but did not differ from boys with ASD. Dampened vagal tone predicted pragmatic impairment in ASD, and associations emerged between cardiac activity and receptive/expressive vocabulary across groups. Findings support autonomic dysfunction as a mechanism underlying pragmatic impairment in ASD and suggest that biophysiological profiles are shared in ASD and FXS, which has implications for understanding the role of fragile X mental retardation-1 (FMR1, the FXS gene) in the pathophysiology of ASD.
机译：这项研究检验了以下假设，即在自闭症谱系障碍（ASD）和易碎X综合征（FXS）中，语用（即社交）语言障碍与唤醒失调有关。 40名年龄在4至15岁的ASD男孩，39名FXS男孩和27名具有典型发育（TD）的男孩参加了比赛。患有FXS的男孩与患有TD的男孩相比非常激动，但与患有ASD的男孩没有什么不同。迷走神经张力减弱预示了ASD的实用性损害，并且各组之间的心脏活动与接受/表达词汇之间存在关联。研究结果支持自主神经功能障碍作为ASD实用性损伤的潜在机制，并表明ASD和FXS具有共同的生物生理特征，这对于理解ASD病理生理中的脆弱X智力低下-1（FMR1，FXS基因）的作用具有重要意义。 。

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