A rapid and sensitive LC-MS/MS method for the determination of Pulsatilla saponin D in rat plasma and its application in a rat pharmacokinetic and bioavailability study

Ouyang Hui; Guo Yicheng; He Mingzhen; Zhang Jinlian; Huang Xiaofang; Zhou Xin; Jiang Hongliang; Feng Yulin; Yang Shilin

首页> 外文期刊>Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences >A rapid and sensitive LC-MS/MS method for the determination of Pulsatilla saponin D in rat plasma and its application in a rat pharmacokinetic and bioavailability study

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A rapid and sensitive LC-MS/MS method for the determination of Pulsatilla saponin D in rat plasma and its application in a rat pharmacokinetic and bioavailability study

机译：快速灵敏的LC-MS / MS法测定大鼠血浆中的白头翁皂苷D及其在大鼠药代动力学和生物利用度研究中的应用

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摘要

A simple, sensitive and specific liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of Pulsatilla saponin D, a potential antitumor constituent isolated from Pulsatilla chinensis in rat plasma. Rat plasma samples were pretreated by protein precipitation with methanol. The method validation was performed in accordance with US Food and Drug Administration guidelines and the results met the acceptance criteria. The method was successfully applied to assess the pharmacokinetics and oral bioavailability of Pulsatilla saponin D in rats. Copyright (c) 2014 John Wiley & Sons, Ltd.

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《Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences》 |2015年第3期|共6页
作者
Ouyang Hui; Guo Yicheng; He Mingzhen; Zhang Jinlian; Huang Xiaofang; Zhou Xin; Jiang Hongliang; Feng Yulin; Yang Shilin;
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正文语种 eng
中图分类化学;
关键词
Pulsatilla saponin D; LC-MS/MS; pharmacokinetics; bioavailability;

机译：白头翁皂苷D;LC-MS / MS;药代动力学;生物利用度;

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1. A rapid and sensitive LC-MS/MS method for the determination of Pulsatilla saponin D in rat plasma and its application in a rat pharmacokinetic and bioavailability study [J] . Ouyang Hui, Guo Yicheng, He Mingzhen, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2015,第3期

机译：快速灵敏的LC-MS / MS法测定大鼠血浆中的白头翁皂苷D及其在大鼠药代动力学和生物利用度研究中的应用
2. Validated rapid resolution LC-ESI-MS/MS method for simultaneous determination of five pulchinenosides from Pulsatilla chinensis (Bunge) Regel in rat plasma: Application to pharmacokinetics and bioavailability studies [J] . Liu Y., Song Y., Xu Q., Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2013,第Null期

机译：经验证的快速拆分LC-ESI-MS / MS方法可同时测定大鼠血浆中白头翁（Bunge）Regel中的五种甜菜苦甙：在药代动力学和生物利用度研究中的应用
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A rapid and sensitive LC-MS/MS method for the determination of Pulsatilla saponin D in rat plasma and its application in a rat pharmacokinetic and bioavailability study

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