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首页> 外文期刊>Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis >Proteomic analysis of leptomeningeal amyloid fibril extracts of cerebral amyloid angiopathy (CAA) patients with or without corticosteroid therapy
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Proteomic analysis of leptomeningeal amyloid fibril extracts of cerebral amyloid angiopathy (CAA) patients with or without corticosteroid therapy

机译：接受或不接受皮质类固醇治疗的脑淀粉样血管病（CAA）患者的软脑膜淀粉样蛋白原纤维提取物的蛋白质组学分析

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摘要

We wish to report the use of liquid chromatography-ion trap mass spectrometry analysis (LC-MS/MS) to analyze amyloid fibrils extracted from the leptomeninges of two cases of cerebral amyloid angiopathy (CAA), one with and one without corticosteroid treatment. We analyzed the crude amyloid extracts using the LC-MS/MS proteomic method and compared their protein profiles.First, we analyzed Abeta and its derivatives. Amyloid fibrils were isolated from the leptomeninges of an untreated 84-year-old female with CAA and an corticosteroid-treated 69-year-old female with CAA [1]. Briefly, amyloid fibrils were isolated from the meninges as described previously [2]. The formic acid extracts (crude amyloid fraction) were used for LC-MS/MS.
机译：我们希望报告使用液相色谱-离子阱质谱分析（LC-MS / MS）分析从2例脑淀粉样血管病（CAA）的轻薄脑膜中提取的淀粉样原纤维，其中1例接受皮质类固醇治疗，另一例未经皮质类固醇治疗。我们使用LC-MS / MS蛋白质组学方法分析了淀粉样蛋白的粗提物并比较了它们的蛋白质谱。首先，我们分析了Abeta及其衍生物。从未经治疗的84岁女性CAA和接受皮质类固醇治疗的69岁女性CAA的软脑膜分离淀粉样蛋白原纤维[1]。简而言之，如先前所述[2]，从脑膜分离淀粉样蛋白原纤维。甲酸提取物（粗淀粉样成分）用于LC-MS / MS。

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