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首页> 外文期刊>Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis >Absence of beta-amyloid deposition in the central nervous system of a transgenic mouse model of distal myopathy with rimmed vacuoles
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Absence of beta-amyloid deposition in the central nervous system of a transgenic mouse model of distal myopathy with rimmed vacuoles

机译：带有边缘性空泡的远侧肌病转基因小鼠模型的中枢神经系统中没有β淀粉样蛋白沉积

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摘要

Lymph node enlargement is a common medical problem, and in a large number of patients, the causes of lymphadenopathy remain undiagnosed. We report a thorough microbiological analysis of 1,688 lymph node biopsy specimens collected in our bartonellosis reference center. We studied lymph node biopsy samples from patients with suspected regional infectious lymph node enlargement from January 2008 to December 2012. To evaluate a useful strategy for the diagnosis of infectious lymphadenitis, specimens were cultured and subjected to molecular assays. Histologic analysis was done when possible. A total of 642 (38%) biopsy specimens were infected with a bacterial agent, and quantitative PCR (qPCR) was significantly better than 16S rRNA gene PCR (rrs) for the detection of Bartonella henselae (P = 0.05), Mycobacterium tuberculosis (P = 0.05), and Mycobacterium avium (P = 0.007). Molecular assays were significantly better than bacterial cultures for the diagnosis of Francisella tularensis (P = 0.017) but were less effective for detecting M. tuberculosis (P = 0.004) and M. avium (P = 0.001). Histologic analysis was done for 412 lymph nodes, and 20% of these were compatible with an infectious lymphadenitis, whereas a neoplasm was found in 29% of these lymph nodes. M. tuberculosis was detected significantly more in female than in male patients (P = 0.01), and patients with cat scratch disease (CSD) were younger than patients with M. tuberculosis, Tropheryma whipplei, and F. tularensis. Negative rrs PCR does not exclude the diagnosis of infectious lymphadenitis. Histologic analysis of lymph node biopsy specimens is critical, as a diagnosis of infectious lymphadenitis does not preclude other concurrent diseases.
机译：淋巴结肿大是一个普遍的医学问题，在许多患者中，淋巴结病的原因仍未诊断。我们报告了在我们的巴尔通体症参考中心收集的1,688个淋巴结活检标本的彻底的微生物学分析。我们研究了从2008年1月至2012年12月疑似区域性感染性淋巴结肿大的患者的淋巴结活检样本。为评估诊断感染性淋巴结炎的有用策略，对样本进行了培养并进行了分子测定。在可能的情况下进行组织学分析。总共642次（38％）活检标本被细菌感染，定量PCR（qPCR）明显优于16S rRNA基因PCR（rrs），用于检测汉赛巴尔通体（P = 0.05），结核分枝杆菌（P = 0.05）和鸟分枝杆菌（P = 0.007）。分子测定法在诊断弗拉索氏菌方面比细菌培养法要好得多（P = 0.017），但在检测结核分枝杆菌（P = 0.004）和鸟分枝杆菌（P = 0.001）时效果较差。对412个淋巴结进行了组织学分析，其中20％与传染性淋巴结炎相容，而在这些淋巴结中有29％发现了肿瘤。女性结核分枝杆菌的检出率明显高于男性患者（P = 0.01），患有猫抓挠病（CSD）的患者比结核分枝杆菌，特发性疟原虫和图莱氏菌的患者年轻。 rrs PCR阴性并不排除感染性淋巴结炎的诊断。淋巴结活检标本的组织学分析至关重要，因为诊断感染性淋巴结炎并不排除其他并发疾病。

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