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Early diagnostics of kidney damage in longstanding rheumatoid arthritis and amyloidosis.

机译:长期类风湿关节炎和淀粉样变性病中肾脏损害的早期诊断。

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摘要

We studied a group of patients with longstanding rheumatoid arthritis (27 patients), a group of patients with different degree of kidney insufficiency (8 patients), and 19 healthy people. We reviewed the main contemporary methods of kidney function examination and carried out comparison between biochemical characteristics (serum creatinine level, cystatin C), calculated data of glomerular nitration rate (modification of diet in renal disease (MDRD), cystatin C, and Cockroft-Gault formulas), results of screening for microalbuminuria, and presence or absence of amyloid deposits in subcutaneous fat tissue. As a result of our investigation, we showed that a complex of laboratory methods should be used for kidney damage diagnostics. The most informative of them are serum cystatin C and calculation of glomerular filtration rate (GFR) by MDRD and cystatin C formulas. Calculation of GFR by Cockroft-Gault formula showed to be less informative.
机译:我们研究了一组患有长期类风湿性关节炎的患者(27例),一组不同程度的肾功能不全的患者(8例)和19名健康人。我们回顾了当代主要的肾功能检查方法,并进行了生化特征(血清肌酐水平,半胱氨酸蛋白酶抑制剂C),肾小球硝化率(肾脏疾病饮食调整(MDRD),半胱氨酸蛋白酶抑制剂C和Cockroft-Gault)计算数据之间的比较式),筛查微量白蛋白尿的结果以及皮下脂肪组织中是否存在淀粉样蛋白沉积物。作为我们调查的结果,我们表明应使用复杂的实验室方法进行肾脏损害诊断。其中最有用的信息是血清胱抑素C以及通过MDRD和胱抑素C公式计算的肾小球滤过率(GFR)。用Cockroft-Gault公式计算GFR的信息量较少。

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