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首页> 外文期刊>Anaesthesia and intensive care >Mechanism of cardiac preconditioning with volatile anaesthetics.
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Mechanism of cardiac preconditioning with volatile anaesthetics.

机译：挥发性麻醉药对心脏的预处理机制。

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摘要

In recent years, there has been increased interest in the mechanisms involved in anaesthetic-induced cardioprotection. It is not thoroughly understood how volatile anaesthetics protect the myocardium from ischaemia or reperfusion injury, but the overall mechanism is likely to be multifactorial. This review examines the recent experimental and clinical research underlying the cellular and molecular mechanisms involved in anaesthetic-induced preconditioning. A variety of intracellular signalling pathways have been implicated in the protective phenomenon. Ischaemic preconditioning and anaesthetic-induced preconditioning share similar molecular mechanisms, including activation of guanine nucleotide-binding proteins, triggering of second messenger pathways, activation of multiple kinases, mediation of nitric oxide formation and reactive oxygen species release, maintenance of intracellular and/or mitochondrial Ca2+ homeostasis and moderation of the opening of adenosine-triphosphate-sensitive potassium channels. A more thorough understanding of the multiple signalling steps and the ultimate cytoprotective mechanisms underlying anaesthetic-induced preconditioning may lead to improvements in the management of ischaemia and/or reperfusion injury.
机译：近年来，人们对与麻醉药诱导的心脏保护相关的机制越来越感兴趣。尚未完全了解挥发性麻醉剂如何保护心肌免受缺血或再灌注损伤，但总体机制可能是多因素的。这篇评论检查了麻醉诱导的预处理中涉及的细胞和分子机制的最新实验和临床研究。多种细胞内信号传导途径已涉及保护现象。缺血预处理和麻醉药诱导的预处理具有相似的分子机制，包括鸟嘌呤核苷酸结合蛋白的激活，第二信使途径的触发，多种激酶的激活，一氧化氮形成和活性氧的释放介导，细胞内和/或线粒体的维持Ca2 +稳态和三磷酸腺苷敏感钾通道开放的缓和。对多种信号传导步骤和麻醉药诱导的预处理的潜在最终细胞保护机制的更透彻的理解可能会导致缺血和/或再灌注损伤的治疗改善。

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