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首页> 外文期刊>Anaesthesia: Journal of the Association of Anaesthetists of Great Britain and Ireland >Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid.
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Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid.

机译：高渗盐水对静脉血脂复活布比卡因毒性兔模型心电图QRS时限的影响。

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摘要

Intravenous lipid emulsion is established therapy for bupivacaine induced cardiotoxicity. The benefit of combined hypertonic saline and lipid treatment is unexplored. In this experiment, sedated rabbits were resuscitated from bupivacaine-induced asystole with intravenous lipid according to the Association of Anaesthetists of Great Britain and Ireland's guideline, or by identical lipid dosing with hypertonic saline: 6 mEq x kg(-1) 21% sodium chloride. Early electrocardiography QRS prolongation was less with lipid plus hypertonic saline (mean (SD) QRS 0.19 (0.07) s lipid only vs 0.09 (0.01) s lipid plus hypertonic saline; p = 0.003) at 9 min though not different from the lipid only group at 20 min. No difference was observed in rates of circulatory return (7/10 lipid only and 9/10 lipid plus hypertonic saline; p = 0.58) or survival (5/10 lipid only and 6/10 lipid plus hypertonic saline; p = 1.00). Some benefit to cardiac conduction may be afforded by hypertonic saline co-administered with lipid emulsion in bupivacaine-induced cardiotoxicity.
机译：静脉内脂质乳剂已确立了布比卡因诱发的心脏毒性的治疗方法。高渗盐水和脂质治疗相结合的益处尚待探讨。在该实验中，根据大不列颠及爱尔兰麻醉师协会的指导，以静脉注射脂质从布比卡因诱导的停搏中恢复了镇静的兔子，或通过高渗盐水相同的脂质给药：6 mEq x kg（-1）21％氯化钠。在9分钟时，使用脂质加高渗盐水的早期心电图QRS延长较少（平均（SD）QRS仅0.19（0.07）s脂质vs 0.09（0.01）s脂质加高渗盐水; p = 0.003），尽管与仅脂质组没有差异在20分钟后循环返回率（仅7/10脂质和9/10脂质加高渗盐水; p = 0.58）或存活率（仅5/10脂质和6/10脂质加高渗盐水; p = 1.00）未观察到差异。在布比卡因引起的心脏毒性反应中，高渗盐水与脂质乳剂共同使用可给心脏传导带来一些益处。

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