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首页> 外文期刊>Anaesthesia: Journal of the Association of Anaesthetists of Great Britain and Ireland >Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid.
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Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid.

机译：高渗盐水对静脉内脂质复苏尿布毒性兔模型心电图QRS持续时间的影响。

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摘要

Intravenous lipid emulsion is established therapy for bupivacaine induced cardiotoxicity. The benefit of combined hypertonic saline and lipid treatment is unexplored. In this experiment, sedated rabbits were resuscitated from bupivacaine-induced asystole with intravenous lipid according to the Association of Anaesthetists of Great Britain and Ireland's guideline, or by identical lipid dosing with hypertonic saline: 6 mEq x kg(-1) 21% sodium chloride. Early electrocardiography QRS prolongation was less with lipid plus hypertonic saline (mean (SD) QRS 0.19 (0.07) s lipid only vs 0.09 (0.01) s lipid plus hypertonic saline; p = 0.003) at 9 min though not different from the lipid only group at 20 min. No difference was observed in rates of circulatory return (7/10 lipid only and 9/10 lipid plus hypertonic saline; p = 0.58) or survival (5/10 lipid only and 6/10 lipid plus hypertonic saline; p = 1.00). Some benefit to cardiac conduction may be afforded by hypertonic saline co-administered with lipid emulsion in bupivacaine-induced cardiotoxicity.
机译：静脉内脂质乳液是对Bupivacaine诱导心脏毒性的疗法建立治疗。组合高渗盐水和脂质治疗的好处是未探斗的。在该实验中，根据大不列颠和爱尔兰指南的麻醉师协会，或通过具有高渗盐水的相同脂质给药的静脉内脂质从Bupivacaine诱导的asystole复苏，或通过高渗盐水：6meq x kg（-1）21％氯化钠。早期心电图QRS延长较少，脂质加高渗盐水（平均值（SD）QRS 0.19（0.07）次（0.07）只有0.09（0.01）次脂质加高渗盐水; P = 0.003）在9分钟内，虽然与脂质仅不同组不同在20分钟。在循环返回率（仅7/10只脂质和9/10脂质加高渗盐水中，没有差异可以通过在Bupivacaine诱导的心脏毒性中共同施用的高渗盐水来提供对心脏传导的一些益处。

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