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首页> 外文期刊>Anaesthesia and intensive care >Cerebral oximetry to reduce perioperative morbidity.
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Cerebral oximetry to reduce perioperative morbidity.

机译：脑血氧饱和度降低围手术期发病率。

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The use of cerebral oximetry to guide intraoperative management has been shown to improve patient outcomes in cardiac surgery. This pilot trial assessed the feasibility of performing a similar study of outcome in patients over the age of 70 years undergoing non-cardiac surgery. Patients over the age of 70 years undergoing total knee or hip arthroplasty or bowel resection surgery were randomly assigned to have cerebral oximetry values monitored (intervention group) or not monitored (control) while under general anaesthesia. Indicators of proof of concept were: rate of complications, rate of cerebral desaturation, relationship between cerebral desaturation and complications, and anaesthetist response to cerebral desaturation. Forty patients were recruited and randomised to a control group (n=20) or an intervention group (n=20). The proportion of the study population who had a complication was 40% (95% confidence interval [CI] 26% to 55%). Cerebral desaturation (<75% of baseline) occurred in only two patients (5.0% (CI 1.4% to 16%)), one in each group, and neither of those patients recorded a complication. Changes to anaesthetic management on the basis of cerebral oximetry values occurred in only two patients in the intervention group (10% (CI 2.8% to 30%)). Maintenance of cerebral oximetry values appeared to be closer to baseline in the intervention group than in the control group but this difference was not significant (P=0.15). Our results indicated that complications occurred frequently in the study population but did not appear to be associated with cerebral desaturation events. These findings do not support a larger intervention study using the current study population.
机译：使用脑血氧饱和度法指导术中治疗已显示可改善心脏手术患者的预后。该试验性试验评估了对70岁以上非心脏手术患者进行类似结果研究的可行性。 70岁以上接受全膝或髋关节置换术或肠切除术的患者被随机分配在全麻下接受监测（干预组）或未监测（对照）的脑血氧饱和度值。概念证明的指标包括：并发症发生率，脑脱饱和率，脑脱饱和与并发症之间的关系以及麻醉师对脑脱饱和的反应。招募四十名患者，随机分为对照组（n = 20）或干预组（n = 20）。发生并发症的研究人群比例为40％（95％置信区间[CI]为26％至55％）。仅两名患者（5.0％（CI 1.4％至16％））发生脑去饱和（基线的<75％），每组一名，并且这些患者均未发现并发症。在干预组中，仅有2例患者根据脑血氧饱和度值改变了麻醉管理（10％（CI为2.8％至30％））。与对照组相比，干预组的脑血氧饱和度值的维持似乎更接近基线，但这一差异并不显着（P = 0.15）。我们的结果表明，并发症在研究人群中经常发生，但似乎与脑去饱和事件无关。这些发现不支持使用当前研究人群进行的较大干预研究。

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