...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences >Metabolism and biochemical/physiological roles of chondroitin sulfates: analysis of endogenous and supplemental chondroitin sulfates in blood circulation.
【24h】

Metabolism and biochemical/physiological roles of chondroitin sulfates: analysis of endogenous and supplemental chondroitin sulfates in blood circulation.

机译：硫酸软骨素的代谢和生化/生理作用：血液循环中内源性和补充性硫酸软骨素的分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chondroitin sulfate (CS) is a linear heteropolysaccharide consisting of repeating disaccharide units of glucuronic acid and galactosamine, which is commonly sulfated at C-4 and/or C-6 of galactosamine. The administration of CS as a supplement or a drug for the treatment of osteoarthrosis, the prevention of subsequent coronary events, treatment of psoriasis and ophthalmic diseases has been suggested. Much debate on the metabolism of CS and therefore the effectiveness of these treatments, especially after oral administration, has arisen due to the macromolecular nature of CS. Difficulties in analysing CS in blood due to the low endogenous concentrations and the covalent and anionic complexes with proteins have hampered the resolution of these issues. In this review, the information on the pharmacokinetics of CS obtained from studies in experimental animals and in humans is presented. Emphasis has been given to the analytical methods used for the determination of glycosaminoglycans, intact CS and CS-derived disaccharides in blood serum and plasma. Copyright (c) 2006 John Wiley & Sons, Ltd.
机译：硫酸软骨素（CS）是一种线性杂多糖，由葡萄糖醛酸和半乳糖胺的重复二糖单元组成，通常在半乳糖胺的C-4和/或C-6处被硫酸化。已经建议使用CS作为补充剂或药物来治疗骨关节炎，预防随后的冠状动脉事件，治疗牛皮癣和眼科疾病。由于CS的大分子性质，引起了关于CS的代谢以及因此这些治疗的有效性的许多争论，尤其是在口服给药之后。由于内源性浓度低以及与蛋白质的共价和阴离子配合物的存在，分析血液中CS的困难阻碍了这些问题的解决。在这篇综述中，介绍了从实验动物和人类研究中获得的有关CS药代动力学的信息。重点介绍了用于测定血清和血浆中糖胺聚糖，完整CS和CS衍生的二糖的分析方法。版权所有（c）2006 John Wiley＆Sons，Ltd.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号