A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide-Reductase

Wei Yifeng; Li Bin; Prakash Divya; Ferry James G.; Elliott Sean J.; Stubbe JoAnne

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A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide-Reductase

机译：二铁素二硫化物还原酶为甲基喹啉纳米氏菌类核糖核苷酸还原酶提供电子

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Two subtypes of class III anaerobic ribonucleotide reductases (RNRs) studied so far couple the reduction of ribonucleotides to the oxidation of formate, or the oxidation of NADPH via thioredoxin and thioredoxin reductase. Certain methanogenic archaea contain a phylogenetically distinct third subtype of class III RNR, with distinct active-site residues. Here we report the cloning and recombinant expression of the Methanosarcina barkeri class III RNR and show that the electrons required for ribonucleotide reduction can be delivered by a [4Fe-4S] protein ferredoxin disulfide reductase, and a conserved thioredoxin-like protein NrdH present in the RNR operon. The diversity of class III RNRs reflects the diversity of electron carriers used in anaerobic metabolism.

机译：迄今为止，研究了III类厌氧核糖核苷酸还原酶（RNR）的亚型核糖核苷酸对甲酸甲酸酯的氧化，或通过硫辛蛋白和硫辛蛋白还原酶的氧化。某些甲烷型古代含有III类RNR的系统源性不同的第三亚型，具有明显的有效性位点残留物。在这里，我们报告了甲蛋白酶甲蛋白酶甲基氏菌III III RNR的克隆和重组表达，并表明核糖核苷酸还原所需的电子可以通过[4FE-4S]蛋白质福兰昔林二硫化物还原酶和保守的硫醚样蛋白NRDH递送 rnr操纵子。 III类RNR的多样性反映了厌氧代谢中使用的电子载体的多样性。

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《Biochemistry》 |2015年第47期|共10页
作者
Wei Yifeng; Li Bin; Prakash Divya; Ferry James G.; Elliott Sean J.; Stubbe JoAnne;
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MIT Dept Chem Cambridge MA 02139 USA;

Boston Univ Dept Chem Boston MA 02215 USA;

Penn State Univ Dept Biochem &

Mol Biol University Pk PA 16802 USA;

Penn State Univ Dept Biochem &

Mol Biol University Pk PA 16802 USA;

Boston Univ Dept Chem Boston MA 02215 USA;

MIT Dept Chem Cambridge MA 02139 USA;

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正文语种 eng
中图分类生物化学;
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1. A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide-Reductase [J] . Wei Yifeng, Li Bin, Prakash Divya, Biochemistry . 2015,第47期

机译：二铁素二硫化物还原酶为甲基喹啉纳米氏菌类核糖核苷酸还原酶提供电子
2. Characterization and determination of the redox properties of the 2[4Fe‐4S] ferredoxin from Methanosarcina barkeri strain MS [J] . Daas Piet J.H., Hagen Wilfred R., Keltjens Jan T., FEBS Letters . 1994,第2a3期

机译：巴氏甲烷八叠球菌2 [4Fe-4S]铁氧还蛋白的氧化还原特性及表征
3. Ferredoxin‐dependent methane formation from acetate in cell extracts of Methanosarcina barkeri (strain MS) [J] . Fischer R., Thauer R.K. FEBS Letters . 1990,第2期

机译：铁甲烷甲烷八叠球菌（MS菌株）细胞提取物中乙酸盐形成的铁氧还蛋白依赖性甲烷
4. Reduction of nitroaromatic explosives by Plasmodium falciparum ferredoxin: NADP+ reductase: estimation of their single-electron reduction potentials [C] . Jonas Sarlauskas, Mindaugas Lesanavicius, Alessandro Aliverti, Seminar on new trends in research of energetic materials . 2018

机译：恶性疟原虫铁氧还蛋白还原硝基芳香族炸药：NADP +还原酶：估计其单电子还原电位
5. Contribution of the Pseudomonas aeruginosa class II and class III ribonucleotide reductases to anaerobic growth and biofilms [D] . Ngai, Helen 2008

机译：铜绿假单胞菌II类和III类核糖核苷酸还原酶对厌氧菌生长和生物膜的贡献
6. A Ferredoxin Disulfide Reductase Delivers Electronsto the Methanosarcina barkeri Class III RibonucleotideReductase [O] . Yifeng Wei, *, Bin Li, -1

机译：铁氧还蛋白二硫化物还原酶提供电子到甲烷化甲烷巴氏菌III类核糖核苷酸还原酶
7. A Ferredoxin Disulfide Reductase Delivers Electrons to the to the Methanosarcina barkeri Class III Ribonucleotide Reductase [O] . Li Bin, Prakash Divya, Ferry James G., 2015

机译：铁氧还蛋白二硫化物还原酶将电子传递给methanosarcina barkeri III类核糖核苷酸还原酶

A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide-Reductase

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